Auge, J., Vent, J., Agache, I., Airaksinen, L., Campo Mozo, P., Chaker, A., Cingi, C., Durham, S., Fokkens, W., Gevaert, P., Giotakis, A., Hellings, P., Herknerova, M., Hox, V., Klimek, L., La Melia, C., Mullol, J., Muluk, N. B., Muraro, A., Naito, K., Pfaar, O., Riechelmann, H., Rondon, C., Rudenko, M., Samolinski, B., Tasca, I., Tomazic, P., Vogt, K., Wagenmann, M., Yeryomenko, G., Zhang, L. and Moesges, R. (2018). EAACI Position paper on the standardization of nasal allergen challenges. Allergy, 73 (8). S. 1597 - 1609. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in the literature caused EAACI to initiate a task force to answer unmet needs and find a consensus in executing nasal allergen challenge. On the basis of a systematic review containing nasal allergen challenges of the past years, task force members reviewed evidence, discussed open issues, and studied variations of several subjective and objective assessment parameters to propose a standardized way of a nasal allergen challenge procedure in clinical practice. Besides an update on indications, contraindications, and preparations for the test procedure, main recommendations are a bilaterally challenge with standardized allergens, with a spray device offering 0.1mL per nostril. A systematic catalogue for positivity criteria is given for the variety of established subjective and objective assessment methods as well as a schedule for the challenge procedure. The task force recommends a unified protocol for NAC for daily clinical practice, aiming at eliminating the previous difficulty of comparing NAC results due to unmet needs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Auge, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vent, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agache, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campo Mozo, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaker, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durham, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gevaert, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giotakis, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellings, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herknerova, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hox, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
La Melia, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muluk, N. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muraro, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naito, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riechelmann, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rondon, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudenko, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samolinski, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tasca, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomazic, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogt, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagenmann, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeryomenko, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhang, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-177034
DOI: 10.1111/all.13416
Journal or Publication Title: Allergy
Volume: 73
Number: 8
Page Range: S. 1597 - 1609
Date: 2018
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL-IMMUNOLOGY; PROVOCATION TEST; NONALLERGIC RHINITIS; RHINOCONJUNCTIVITIS COMMITTEE; OCCUPATIONAL RHINITIS; ACOUSTIC RHINOMETRY; IDIOPATHIC RHINITIS; EUROPEAN ACADEMY; SPANISH SOCIETY; DOUBLE-BLINDMultiple languages
Allergy; ImmunologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17703

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