Wagner, Jonathan, Agostoni, Piergiuseppe ORCID: 0000-0002-8345-6382, Arena, Ross ORCID: 0000-0002-6675-1996, Belardinelli, Romualdo, Dumitrescu, Daniel, Hager, Alfred ORCID: 0000-0002-2481-2017, Myers, Jonathan, Rauramaa, Rainer, Riley, Marshall, Takken, Tim and Schmidt-Trucksass, Arno ORCID: 0000-0002-4662-3911 (2018). The Role of Gas Exchange Variables in Cardiopulmonary Exercise Testing for Risk Stratification and Management of Heart Failure with Reduced Ejection Fraction. Am. Heart J., 202. S. 116 - 127. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-5330

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Abstract

Heart failure with reduced ejection fraction (HFrEF) is common in the developed world and results in significant morbidity and mortality. Accurate risk assessment methods and prognostic variables are therefore needed to guide clinical decision making for medical therapy and surgical interventions with the ultimate goal of decreasing risk and improving health outcomes. The purpose of this review is to examine the role of cardiopulmonary exercise testing (CPET) and its most commonly used ventilatory gas exchange variables for the purpose of risk stratification and management of HFrEF. We evaluated five widely studied gas exchange variables from CPET in HFrEF patients based on nine previously used systematic criteria for biomarkers. This paper provides clinicians with a comprehensive and critical overview, class recommendations and evidence levels. Although some CPET variables met more criteria than others, evidence supporting the clinical assessment of variables beyond peak VO2 is well-established. A multi-variable approach also including the V-E-VCO2 slope and EOV is therefore recommended. (C) 2018 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wagner, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agostoni, PiergiuseppeUNSPECIFIEDorcid.org/0000-0002-8345-6382UNSPECIFIED
Arena, RossUNSPECIFIEDorcid.org/0000-0002-6675-1996UNSPECIFIED
Belardinelli, RomualdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dumitrescu, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hager, AlfredUNSPECIFIEDorcid.org/0000-0002-2481-2017UNSPECIFIED
Myers, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauramaa, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riley, MarshallUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takken, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt-Trucksass, ArnoUNSPECIFIEDorcid.org/0000-0002-4662-3911UNSPECIFIED
URN: urn:nbn:de:hbz:38-177055
DOI: 10.1016/j.ahj.2018.05.009
Journal or Publication Title: Am. Heart J.
Volume: 202
Page Range: S. 116 - 127
Date: 2018
Publisher: MOSBY-ELSEVIER
Place of Publication: NEW YORK
ISSN: 1097-5330
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
UPTAKE EFFICIENCY SLOPE; PEAK OXYGEN-CONSUMPTION; TIDAL CARBON-DIOXIDE; CARDIORESPIRATORY FUNCTIONAL RESERVE; EXERTIONAL OSCILLATORY VENTILATION; CARDIAC RESYNCHRONIZATION THERAPY; MEMBRANE DIFFUSING-CAPACITY; BETA-BLOCKER THERAPY; QUALITY-OF-LIFE; PROGNOSTIC-SIGNIFICANCEMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/17705

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