Universität zu Köln

Park, Su-Chan, Klatt, Philipp and Krug, Joachim ORCID: 0000-0002-2143-6490 (2018). Rare beneficial mutations cannot halt Muller's ratchet in spatial populations. EPL, 123 (4). BRISTOL: IOP PUBLISHING LTD. ISSN 1286-4854

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Abstract

Muller's ratchet describes the irreversible accumulation of deleterious mutations in asexual populations. In well-mixed populations the speed of fitness decline is exponentially small in the population size, and any positive rate of beneficial mutations is sufficient to reverse the ratchet in large populations. The behavior is fundamentally different in populations with spatial structure, because the speed of the ratchet remains nonzero in the infinite size limit when the deleterious mutation rate exceeds a critical value. Based on the relation between the spatial ratchet and directed percolation, we develop a scaling theory incorporating both deleterious and beneficial mutations. The theory is verified by extensive simulations in one and two dimensions. Copyright (C) EPLA, 2018

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Park, Su-Chan UNSPECIFIED UNSPECIFIED UNSPECIFIED Klatt, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177167
DOI:	10.1209/0295-5075/123/48001
Journal or Publication Title:	EPL
Volume:	123
Number:	4
Date:	2018
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1286-4854
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIRECTED PERCOLATION; CANCER INITIATION; MORAN MODELS; EVOLUTION; FITNESS; BEHAVIOR; SPEED; ACCUMULATION; ADAPTATION Multiple languages Physics, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17716