Universität zu Köln

Abdillahi, Suado M., Maass, Tobias, Kasetty, Gopinath, Stromstedt, Adam A., Baumgarten, Maria, Tati, Ramesh, Nordin, Sara L., Walse, Bjorn, Wagener, Raimund, Schmidtchen, Artur ORCID: 0000-0001-9209-3141 and Morgelin, Matthias (2018). Collagen VI Contains Multiple Host Defense Peptides with Potent In Vivo Activity. J. Immunol., 201 (3). S. 1007 - 1021. BETHESDA: AMER ASSOC IMMUNOLOGISTS. ISSN 1550-6606

Full text not available from this repository.

Abstract

Collagen VI is a ubiquitous extracellular matrix component that forms extensive microfibrillar networks in most connective tissues. In this study, we describe for the first time, to our knowledge, that the collagen VI von Willebrand factor type A like domains exhibit a broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria in human skin infections in vivo. In silico sequence and structural analysis of VWA domains revealed that they contain cationic and amphipathic peptide sequence motifs, which might explain the antimicrobial nature of collagen VI. In vitro and in vivo studies show that these peptides exhibited significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa through membrane disruption. Our findings shed new light on the role of collagen VI derived peptides in innate host defense and provide templates for development of peptide-based antibacterial therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Abdillahi, Suado M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maass, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasetty, Gopinath UNSPECIFIED UNSPECIFIED UNSPECIFIED Stromstedt, Adam A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumgarten, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Tati, Ramesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordin, Sara L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walse, Bjorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidtchen, Artur UNSPECIFIED orcid.org/0000-0001-9209-3141 UNSPECIFIED Morgelin, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-177276
DOI:	10.4049/jimmunol.1700602
Journal or Publication Title:	J. Immunol.
Volume:	201
Number:	3
Page Range:	S. 1007 - 1021
Date:	2018
Publisher:	AMER ASSOC IMMUNOLOGISTS
Place of Publication:	BETHESDA
ISSN:	1550-6606
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARIN-BINDING PEPTIDES; ANTIMICROBIAL PEPTIDES; EXTRACELLULAR-MATRIX; VONWILLEBRAND-FACTOR; GLOBULAR DOMAINS; ALPHA-3 CHAIN; PROTEINS; SEQUENCE; BILAYERS Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17727