Universität zu Köln

Forsdahl, Guro, Geisendorfer, Thomas, Goeschl, Lorenz, Pfeffer, Sandra, Gaertner, Peter, Thevis, Mario and Gmeiner, Guenter (2018). Unambiguous identification and characterization of a long-term human metabolite of dehydrochloromethyltestosterone. Drug Test. Anal., 10 (8). S. 1244 - 1251. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

In doping control analysis, the characterization of urinary steroid metabolites is of high interest for a targeted and long-term detection of prohibited anabolic androgenic steroids (AAS). In this work, the structure of a long-term metabolite of dehydrochloromethyltestosterone (DHCMT) was elucidated. Altogether, 8 possible metabolites with a 17-methyl-17-hydroxymethyl - structures were synthesized and compared to a major DHCMT long-term metabolite detected in reference urine excretion samples. The confirmed structure of the metabolite was 4-chloro-18-nor-17-hydroxymethyl-17-methyl-5-androst-13-en-3-ol.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Forsdahl, Guro UNSPECIFIED UNSPECIFIED UNSPECIFIED Geisendorfer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeschl, Lorenz UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeffer, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaertner, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Thevis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Gmeiner, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-178232
DOI:	10.1002/dta.2385
Journal or Publication Title:	Drug Test. Anal.
Volume:	10
Number:	8
Page Range:	S. 1244 - 1251
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MASS-SPECTROMETRY; HUMAN URINE; DOPING-CONTROL; METANDIENONE; OXANDROLONE; STANOZOLOL Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17823