Universität zu Köln

Riehle, Alexa, Brochier, Thomas, Nawrot, Martin and Gruen, Sonja (2018). Behavioral Context Determines Network State and Variability Dynamics in Monkey Motor Cortex. Front. Neural Circuits, 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5110

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Abstract

Variability of spiking activity is ubiquitous throughout the brain but little is known about its contextual dependance. Trial-to-trial spike count variability, estimated by the Fano Factor (FF), and within-trial spike time irregularity, quantified by the coefficient of variation (CV), reflect variability on long and short time scales, respectively. We co-analyzed FF and the local coefficient of variation (CV2) in monkey motor cortex comparing two behavioral contexts, movement preparation (wait) and execution (movement). We find that the FF significantly decreases from wait to movement, while the CV2 increases. The more regular firing (expressed by a low CV2) during wait is related to an increased power of local field potential (LFP) beta oscillations and phase locking of spikes to these oscillations. In renewal processes, a widely used model for spiking activity under stationary input conditions, both measures are related as FF approximate to CV2. This expectation was met during movement, but not during wait where FF >> CV2(2). Our interpretation is that during movement preparation, ongoing brain processes result in changing network states and thus in high trial-to-trial variability (expressed by a high FF). During movement execution, the network is recruited for performing the stereotyped motor task, resulting in reliable single neuron output. Our interpretation is in the light of recent computational models that generate non-stationary network conditions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Riehle, Alexa UNSPECIFIED UNSPECIFIED UNSPECIFIED Brochier, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Nawrot, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruen, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179782
DOI:	10.3389/fncir.2018.00052
Journal or Publication Title:	Front. Neural Circuits
Volume:	12
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5110
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCAL-FIELD POTENTIALS; REACH-TO-GRASP; CORTICAL-NEURONS; VISUAL-CORTEX; SPIKE TRAINS; SENSORIMOTOR CORTEX; VOLUNTARY MOVEMENT; NEURAL VARIABILITY; PREMOTOR CORTEX; HAND MUSCLE Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17978