Universität zu Köln

DiFeliceantonio, Alexandra G., Coppin, Geraldine ORCID: 0000-0002-7848-3298, Rigoux, Lionel, Thanarajah, Sharmili Edwin, Dagher, Alain, Tittgemeyer, Marc and Small, Dana M. (2018). Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward. Cell Metab., 28 (1). S. 33 - 48. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Post-ingestive signals conveying information about the nutritive properties of food are critical for regulating ingestive behavior. Here, using an auction task concomitant to fMRI scanning, we demonstrate that participants are willing to pay more for fat + carbohydrate compared with equally familiar, liked, and caloric fat or carbohydrate foods and that this potentiated reward is associated with response in areas critical for reward valuation, including the dorsal striatum and mediodorsal thalamus. We also show that individuals are better able to estimate the energy density of fat compared with carbohydrate and fat + carbohydrate foods, an effect associated with functional connectivity between visual (fusiform gyrus) and valuation (ventromedial prefrontal cortex) areas. These results provide the first demonstration that foods high in fat and carbohydrate are, calorie for calorie, valued more than foods containing only fat or carbohydrate and that this effect is associated with greater recruitment of central reward circuits.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code DiFeliceantonio, Alexandra G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Coppin, Geraldine UNSPECIFIED orcid.org/0000-0002-7848-3298 UNSPECIFIED Rigoux, Lionel UNSPECIFIED UNSPECIFIED UNSPECIFIED Thanarajah, Sharmili Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dagher, Alain UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Small, Dana M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-179960
DOI:	10.1016/j.cmet.2018.05.018
Journal or Publication Title:	Cell Metab.
Volume:	28
Number:	1
Page Range:	S. 33 - 48
Date:	2018
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEUS-ACCUMBENS; ORBITOFRONTAL CORTEX; STRIATAL RESPONSE; BRAIN RESPONSES; EATING BEHAVIOR; CALORIE FOODS; SELF-CONTROL; WEIGHT-GAIN; DOPAMINE; CUES Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/17996