Dafsari, Haidar Salimi, Weiss, Luisa, Silverdale, Monty ORCID: 0000-0002-3295-6897, Rizos, Alexandra, Reddy, Prashanth, Ashkan, Keyoumars, Evans, Julian, Reker, Paul, Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Samuel, Michael, Visser-Vandewalle, Veerle, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo ORCID: 0000-0003-0837-5280, Ray-Chaudhuri, K. and Timmermann, Lars (2018). Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease. Brain Stimul., 11 (4). S. 867 - 875. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-4754

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Abstract

Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in advanced Parkinson's disease (PD). However, considerable inter-individual variability has been observed for QoL outcome. Hypothesis: We hypothesized that demographic and preoperative NMS characteristics can predict postoperative QoL outcome. Methods: In this ongoing, prospective, multicenter study (Cologne, Manchester, London) including 88 patients, we collected the following scales preoperatively and on follow-up 6 months postoperatively: PDQuestionnaire-8 (PDQ-8), NMSScale (NMSS), NMSQuestionnaire (NMSQ), Scales for Outcomes in PD (SCOPA)-motor examination, -complications, and -activities of daily living, levodopa equivalent daily dose. We dichotomized patients into QoL responders/non-responders and screened for factors associated with QoL improvement with (1) Spearman-correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions using aforementioned responders/nonresponders as dependent variable. Results: All outcomes improved significantly on follow-up. However, approximately 44% of patients were categorized as QoL non-responders. Spearman-correlations, linear and logistic regression analyses were significant for NMSS and NMSQ but not for SCOPA-motor examination. Post-hoc, we identified specific NMS (flat moods, difficulties experiencing pleasure, pain, bladder voiding) as significant contributors to QoL outcome. Conclusions: Our results provide evidence that QoL improvement after STN-DBS depends on preoperative NMS characteristics. These findings are important in the advising and selection of individuals for DBS therapy. Future studies investigating motor and non-motor PD clusters may enable stratifying QoL outcomes and help predict patients' individual prospects of benefiting from DBS. (C) 2018 Published by Elsevier Inc.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dafsari, Haidar SalimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverdale, MontyUNSPECIFIEDorcid.org/0000-0002-3295-6897UNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reddy, PrashanthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ashkan, KeyoumarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reker, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petry-Schmelzer, Jan NiklasUNSPECIFIEDorcid.org/0000-0003-0749-3840UNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visser-Vandewalle, VeerleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Martinez-Martin, PabloUNSPECIFIEDorcid.org/0000-0003-0837-5280UNSPECIFIED
Ray-Chaudhuri, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-180249
DOI: 10.1016/j.brs.2018.02.015
Journal or Publication Title: Brain Stimul.
Volume: 11
Number: 4
Page Range: S. 867 - 875
Date: 2018
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1876-4754
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; BODY-WEIGHT GAIN; NUCLEUS; MOTOR; SCALE; QUESTIONNAIRE; LEVODOPA; IMPROVEMENT; VALIDATION; SPES/SCOPAMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18024

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