Universität zu Köln

Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Neuhaus, Victor-Frederic, Bratke, Grischa, Voss, Sebastian, Hokamp, Nils Grosse, Hellmich, Martin, Krug, Barbara, Maintz, David and Borggrefe, Jan ORCID: 0000-0003-2908-7560 (2018). Effects of Contrast Enhancement on In-Body Calibrated Phantomless Bone Mineral Density Measurements in Computed Tomography. J. Clin. Densitom., 21 (3). S. 360 - 367. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1559-0747

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Abstract

We aimed to test the potential of phantomless volumetric bone mineral density (PLvBMD) measurements for the determination of volumetric bone mineral density (vBMD) in routine contrast-enhanced computed tomography (CECT). We evaluated 56 tri-phasic abdominal computed tomography scans, including an unenhanced scan as well as defined CECT scans in the arterial and portalvenous phase. PLvBMD analysis was performed by 4 radiologists using an FDA-approved tool for phantomless evaluation of bone density (IntelliSpace, Philips, The Netherlands). Mean vBMD of the first 3 lumbar vertebrae in each contrast phase was determined and interobserver variance of vBMD independent of contrast phase was analyzed using intraclass correlation, Bland-Altman plots, and Student's t test. CECT scans were associated with a significantly higher PLvBMD compared with unenhanced scans (unenhanced computed tomography: 97.8 mg/cc; arterial CECT: 106.3 mg/cc, portalvenous CECT: 106.3 mg/cc). Overall, there was no significant difference of PLvBMD between data acquisition in arterial and portalvenous phases (increase of 8.6% each, standard deviation ratio 37.7%-38.3%). In Bland-Altman analysis, there was no evidence of a relevant reader-related bias or an increase in standard deviation of PLvBMD measurements in contrast-enhanced scans compared with unenhanced scans. The following conversion formulas for unenhanced PLvBMD were determined: unenhanced PLvBMD = 0.89 x arterial PLvBMD+ 3, 74 mg lcc (r(2) = 0.94) and unenhanced PLvBMD = 0.88 x venous PLvBMD + 4,56 mg/cc (r(2) = 0.93). Compared with the results of phantom-based quantitative computed tomography measurements reported in the literature, the PLvBMD changes associated with contrast enhancement were relatively moderate with an increase of 8.6% in average. The time-point of the contrastenhanced PLvBMD measurements after injection of contrast media did not appear to affect the results. With the adjustment formulas provided in this study, the method can improve osteoporosis screening through detection of reduced bone mass of the vertebrae in routinely conducted CECT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Abdullayev, Nuran UNSPECIFIED orcid.org/0000-0003-4522-537X UNSPECIFIED Neuhaus, Victor-Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Bratke, Grischa UNSPECIFIED UNSPECIFIED UNSPECIFIED Voss, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-180485
DOI:	10.1016/j.jocd.2017.10.001
Journal or Publication Title:	J. Clin. Densitom.
Volume:	21
Number:	3
Page Range:	S. 360 - 367
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1559-0747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VOLUMETRIC QUANTITATIVE CT; ISCD OFFICIAL POSITIONS; VERTEBRAL FRACTURES; CLINICAL-USE; OSTEOPOROSIS; MDCT; MANAGEMENT; ADULTS; TOOL Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18048