Universität zu Köln

Setareh, Hesam, Deger, Moritz ORCID: 0000-0002-2775-2611 and Gerstner, Wulfram (2018). Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. PLoS Comput. Biol., 14 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7358

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Abstract

The time scale of neuronal network dynamics is determined by synaptic interactions and neuronal signal integration, both of which occur on the time scale of milliseconds. Yet many behaviors like the generation of movements or vocalizations of sounds occur on the much slower time scale of seconds. Here we ask the question of how neuronal networks of the brain can support reliable behavior on this time scale. We argue that excitable neuronal assemblies with spike-frequency adaptation may serve as building blocks that can flexibly adjust the speed of execution of neural circuit function. We show in simulations that a chain of neuronal assemblies can propagate signals reliably, similar to the well-known synfire chain, but with the crucial difference that the propagation speed is slower and tunable to the behaviorally relevant range. Moreover we study a grid of excitable neuronal assemblies as a simplified model of the somatosensory barrel cortex of the mouse and demonstrate that various patterns of experimentally observed spatial activity propagation can be explained.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Setareh, Hesam UNSPECIFIED UNSPECIFIED UNSPECIFIED Deger, Moritz UNSPECIFIED orcid.org/0000-0002-2775-2611 UNSPECIFIED Gerstner, Wulfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-181272
DOI:	10.1371/journal.pcbi.1006216
Journal or Publication Title:	PLoS Comput. Biol.
Volume:	14
Number:	7
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7358
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORTICAL NETWORK MODEL; RAT BARREL CORTEX; LAYER 2/3; IN-VIVO; SPATIOTEMPORAL DYNAMICS; SYNAPTIC PLASTICITY; SYNCHRONOUS SPIKING; STABLE PROPAGATION; SENSORY RESPONSES; PATH-INTEGRATION Multiple languages Biochemical Research Methods; Mathematical & Computational Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18127