Universität zu Köln

Firner, Sara, Willwacher, Steffen, de Marees, Markus, Bleuel, Judith, Zaucke, Frank, Brueggemann, Gert-Peter and Niehoff, Anja (2018). Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP). J. Orthop. Res., 36 (7). S. 1937 - 1947. HOBOKEN: WILEY. ISSN 1554-527X

Full text not available from this repository.

Abstract

The purpose of the study was to investigate the effect of an increase in mechanical knee joint loading during running on the serum COMP level. On two different test days, 20 healthy men ran with knee orthoses for 30min on a treadmill (v=2.2m/s). On day 1, the orthoses were passive, whereas on day 2 they were pneumatically driven (active) and thus increased the external knee flexion moments (+30.9Nm) during stance phase. Lower-limb mechanics and serum COMP levels (baseline; 0, 0.5, 1, 2h post running) were analyzed. COMP levels increased immediately after running with passive (+35%; pre: 7.5U/l, 95%CI: 6.4, 8.7, post: 9.8U/l, 95%CI: 8.8, 10.8, p<0.001) and active orthoses (+45%; pre: 7.6U/l; 95%CI: 6.4, 8.8, post: 10.3U/l, 95%CI: 9.2, 11.5, p<0.001), but they did not differ between interventions. While running with active orthoses, greater ankle dorsiflexion angles, knee flexion angles, and moments occurred (p<0.05). Comparing both interventions, the COMP pre-post, meaning the difference () between running with active and passive orthoses in pre to post COMP level change (=level after (post) running minus level before (pre) running), correlated negatively with COMP baseline (difference between the baseline COMP level before running with active and passive orthoses, r=-0.616; p=0.004), and with a positive tendence with the maximum knee flexion (r=0.388; p=0.091). Therefore, changes in COMP concentration after physical activity seem to be highly influenced by the COMP baseline level. In addition, correlation analysis indicates that modifications in knee joint kinematics have a greater effect on cartilage metabolism than an increase in joint moments. (c) 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1937-1946, 2018.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Firner, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Willwacher, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED de Marees, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bleuel, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-181308
DOI:	10.1002/jor.23859
Journal or Publication Title:	J. Orthop. Res.
Volume:	36
Number:	7
Page Range:	S. 1937 - 1947
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1554-527X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COUNTY OSTEOARTHRITIS PROJECT; ARTICULAR-CARTILAGE; BONE METABOLISM; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; HEALTHY-ADULTS; KM RACE; BIOMARKERS; PROGRESSION; MARKERS Multiple languages Orthopedics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18130