Universität zu Köln

Grenzi, Patricia Cristina, Campos, Erika Fernandes, Tedesco-Silva Jr, Helio, Felipe, Claudia Rosso, Soares, Maria Fernanda ORCID: 0000-0001-6231-8987, Medina-Pestana, Jose, Hansen, Hinrich Peter and Gerbase-DeLima, Maria (2018). Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients. Hum. Immunol., 79 (7). S. 550 - 558. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1166

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Abstract

Background: Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are influenced by immunosuppression and whether they correlate with findings in protocol biopsies and with CD30 gene expression in peripheral blood mononuclear cells (PBMC). Methods: We studied 118 kidney transplant recipients that initially received tacrolimus (TAC) and, at month-3, were converted or not to sirolimus (SRL). Results: sCD30 serum levels gradually declined after transplantation, being the decline more pronounced in the SRL group. CD30 gene expression in PBMC was higher in the SRL group than in the TAC group. Patients with IF/TA >= I in the month-24 protocol biopsy had higher sCD30 levels than patients without IF/TA, in the SRL group (P=.03) and in the TAC group (P=.07). CD30 cells were observed in three out of 10 biopsies with inflammatory infiltrate from the SRL group. In mixed lymphocyte cultures, SRL and TAC diminished the number of CD30(+) T cells and the sCD30 levels in the supernatant, but the effect of SRL was stronger. Conclusions: Overall, sCD30 levels are lower in SRL-treated patients, but the association between increased sCD30 levels and IF/TA at month-24 post-transplantation is stronger in SRL than in TAC-treated patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grenzi, Patricia Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Campos, Erika Fernandes UNSPECIFIED UNSPECIFIED UNSPECIFIED Tedesco-Silva Jr, Helio UNSPECIFIED UNSPECIFIED UNSPECIFIED Felipe, Claudia Rosso UNSPECIFIED UNSPECIFIED UNSPECIFIED Soares, Maria Fernanda UNSPECIFIED orcid.org/0000-0001-6231-8987 UNSPECIFIED Medina-Pestana, Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Hinrich Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerbase-DeLima, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-181914
DOI:	10.1016/j.humimm.2018.04.002
Journal or Publication Title:	Hum. Immunol.
Volume:	79
Number:	7
Page Range:	S. 550 - 558
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1166
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language T-CELL DIFFERENTIATION; CHRONIC ALLOGRAFT NEPHROPATHY; SOLUBLE CD30; CD30-DEPENDENT MECHANISM; POSTTRANSPLANT SCD30; MAMMALIAN TARGET; RENAL-ALLOGRAFTS; HODGKINS-DISEASE; EARLY CONVERSION; LYMPHOID-TISSUE Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18191