Universität zu Köln

Voon, Valerie, Droux, Fabien, Chabardes, Stephan, Bougerol, Thierry, Kohl, Sina, David, Olivier ORCID: 0000-0003-0776-0216, Krack, Paul ORCID: 0000-0002-3508-7295 and Polosan, Mircea (2018). Dissociable Effects of Subthalamic Stimulation in Obsessive Compulsive Disorder on Risky Reward and Loss Prospects. Neuroscience, 382. S. 105 - 115. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7544

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Abstract

Our daily decisions involve an element of risk, a behavioral process that is potentially modifiable. Here we assess the role of the associative-limbic subthalamic nucleus (STN) in obsessive compulsive disorder (OCD) testing on and off deep-brain stimulation (DBS) on anticipatory risk taking to obtain rewards and avoid losses. We assessed 12 OCD STN DBS in a randomized double-blind within-subject cross-over design. STN DBS decreased risk taking to rewards (p = 0.02) and greater risk taking to rewards was positively correlated with OCD severity (p = 0.01) and disease duration (p = 0.01). STN DBS was also associated with impaired subjective discrimination of loss magnitude (p < 0.05), an effect mediated by acute DBS rather than chronic DBS. We highlight a role for the STN in mediating dissociable valence prospects on risk seeking. STN stimulation decreases risk taking to rewards and impairs discrimination of loss magnitude. These findings may have implications for behavioral symptoms related to STN DBS and the potential for STN DBS for the treatment of psychiatric disorders. (C) 2018 Published by Elsevier Ltd on behalf of IBRO.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Voon, Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Droux, Fabien UNSPECIFIED UNSPECIFIED UNSPECIFIED Chabardes, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bougerol, Thierry UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohl, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED David, Olivier UNSPECIFIED orcid.org/0000-0003-0776-0216 UNSPECIFIED Krack, Paul UNSPECIFIED orcid.org/0000-0002-3508-7295 UNSPECIFIED Polosan, Mircea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182389
DOI:	10.1016/j.neuroscience.2018.03.010
Journal or Publication Title:	Neuroscience
Volume:	382
Page Range:	S. 105 - 115
Date:	2018
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-7544
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; DECISION-MAKING; PARKINSONS-DISEASE; DOPAMINERGIC MEDICATION; NUCLEUS STIMULATION; IMPULSIVITY; COCAINE; TASK; REDUCTION; AMBIGUITY Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18238