Universität zu Köln

Rashid, Khalid, Wolf, Anne ORCID: 0000-0003-2551-9821 and Langmann, Thomas (2018). Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations. Front. Cell. Neurosci., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5102

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Abstract

A chronic pro-inflammatory environment is a hallmark of retinal degenerative diseases and neurological disorders that affect vision. Inflammatory responses during retinal pathophysiology are orchestrated by microglial cells which constitute the resident immune cell population. Following activation, microglia cells lose their ramified protrusions, proliferate and rapidly migrate to the damaged areas and resolve tissue damage. However, sustained presence of tissue stress primes microglia to become overreactive and results in the excessive production of pro-inflammatory mediators that favor retinal degenerative changes. Consequently, interventions aimed at overriding microglial pro-inflammatory and pro-oxidative properties may attenuate photoreceptor demise and preserve retinal integrity. We highlight the positive effects of ligands for the translocator protein 18 kDa (TSPO) and the cytokine interferon beta (IFN-beta) in modulating microgliosis during retinal pathologies and discuss their plausible mechanisms of action.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rashid, Khalid UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Anne UNSPECIFIED orcid.org/0000-0003-2551-9821 UNSPECIFIED Langmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182707
DOI:	10.3389/fncel.2018.00176
Journal or Publication Title:	Front. Cell. Neurosci.
Volume:	12
Date:	2018
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 18 KDA TSPO; MONONUCLEAR PHAGOCYTES; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; INTERFERON-BETA; SOCS PROTEINS; CELLS; MECHANISMS; PATHWAYS; PROTECTS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18270