Universität zu Köln

Neuschmelting, Volker, Harmsen, Stefan ORCID: 0000-0001-5812-7299, Beziere, Nicolas ORCID: 0000-0002-2076-7060, Lockau, Hannah, Hsu, Hsiao-Ting, Huang, Ruimin, Razansky, Daniel ORCID: 0000-0001-8676-0964, Ntziachristos, Vasilis and Kircher, Moritz F. (2018). Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation. Small, 14 (23). WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1613-6829

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Abstract

Difficulty in visualizing glioma margins intraoperatively remains a major issue in the achievement of gross total tumor resection and, thus, better dinical outcome of glioblastoma (GBM) patients. Here, the potential of a new combined optical + optoacoustic imaging method for intraoperative brain tumor delineation is investigated. A strategy using a newly developed gold nanostar synthesis method, Raman reporter chemistry, and silication method to produce dual-modality contrast agents for combined surface-enhanced resonance Raman scattering (SERRS) and multispectral optoacoustic tomography (MSOT) imaging is devised. Following intravenous injection of the SERRS-MSOT-nanostars in brain tumor bearing mice, sequential MSOT imaging is performed in vivo and followed by Raman imaging. MSOT is able to accurately depict GBMs three-dimensionally with high specificity. The MSOT signal is found to correlate well with the SERRS images. Because SERRS enables uniquely sensitive high-resolution surface detection, it could represent an ideal complementary imaging modality to MSOT, which enables real-time, deep tissue imaging in 3D. This dual-modality SERRS-MSOT-nanostar contrast agent reported here is shown to enable high precision depiction of the extent of infiltrating GBMs by Raman- and MSOT imaging in a clinically relevant murine GBM model and could pave new ways for improved image-guided resection of brain tumors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neuschmelting, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Harmsen, Stefan UNSPECIFIED orcid.org/0000-0001-5812-7299 UNSPECIFIED Beziere, Nicolas UNSPECIFIED orcid.org/0000-0002-2076-7060 UNSPECIFIED Lockau, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Hsu, Hsiao-Ting UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Ruimin UNSPECIFIED UNSPECIFIED UNSPECIFIED Razansky, Daniel UNSPECIFIED orcid.org/0000-0001-8676-0964 UNSPECIFIED Ntziachristos, Vasilis UNSPECIFIED UNSPECIFIED UNSPECIFIED Kircher, Moritz F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-182957
DOI:	10.1002/smll.201800740
Journal or Publication Title:	Small
Volume:	14
Number:	23
Date:	2018
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1613-6829
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 5-AMINOLEVULINIC ACID; RESECTION; GLIOBLASTOMA; FLUORESCENCE; GLIOMA; MSOT; STRATEGY; VIVO; MRI Multiple languages Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18295