Universität zu Köln

Trempler, Ima, Binder, Ellen, El-Sourani, Nadiya, Schiffler, Patrick, Tenberge, Jan-Gerd, Schiffer, Anne-Marike, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schubotz, Ricarda I. (2018). Association of grey matter changes with stability and flexibility of prediction in akinetic-rigid Parkinson's disease. Brain Struct. Funct., 223 (5). S. 2097 - 2112. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

Parkinson's disease (PD), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. Since the phasic signal of dopamine neurons is proposed to guide learning by signifying mismatches between subjects' expectations and external events, we here investigated whether akinetic-rigid PD patients without mild cognitive impairment exhibit difficulties in dealing with either relevant (requiring flexibility) or irrelevant (requiring stability) prediction errors. Following our previous study on flexibility and stability in prediction (Trempler et al. J Cogn Neurosci 29(2):298-309, 2017), we then assessed whether deficits would correspond with specific structural alterations in dopaminergic regions as well as in inferior frontal cortex, medial prefrontal cortex, and the hippocampus. Twenty-one healthy controls and twenty-one akinetic-rigid PD patients on and off medication performed a task which required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press, whereas sequence omissions had to be ignored. Independent of the disease, midbrain volume was related to a general response bias to unexpected events, whereas right putamen volume correlated with the ability to discriminate between relevant and irrelevant prediction errors. However, patients compared with healthy participants showed deficits in stabilisation against irrelevant prediction errors, associated with thickness of right inferior frontal gyrus and left medial prefrontal cortex. Flexible updating due to relevant prediction errors was also affected in patients compared with controls and associated with right hippocampus volume. Dopaminergic medication influenced behavioural performance across, but not within the patients. Our exploratory study warrants further research on deficient prediction error processing and its structural correlates as a core of cognitive symptoms occurring already in early stages of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Trempler, Ima UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED El-Sourani, Nadiya UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffler, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Tenberge, Jan-Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffer, Anne-Marike UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schubotz, Ricarda I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-183242
DOI:	10.1007/s00429-018-1616-2
Journal or Publication Title:	Brain Struct. Funct.
Volume:	223
Number:	5
Page Range:	S. 2097 - 2112
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFERIOR FRONTAL GYRUS; HUMAN CEREBRAL-CORTEX; WORKING-MEMORY; PREFRONTAL CORTEX; BASAL GANGLIA; COGNITIVE CONTROL; NEURAL MECHANISMS; DOPAMINE FUNCTION; DEMENTIA; THICKNESS Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18324