Universität zu Köln

Kauke, Martin, Safi, Ali-Farid, Grandoch, Andrea, Nickenig, Hans-Joachim, Zoeller, Joachim and Kreppel, Matthias (2018). Sarcomas of the sinonasal tract. Head Neck-J. Sci. Spec. Head Neck, 40 (6). S. 1279 - 1287. HOBOKEN: WILEY. ISSN 1097-0347

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Abstract

BackgroundSinonasal sarcomas are rare and heterogeneous in nature. Continuously collecting data influencing the prognosis is fundamental for optimizing therapeutic assessment of this highly destructive neoplasm. MethodsWe conducted a single-institution retrospective cohort study considering 27 patients with sinonasal sarcoma. ResultsThe overall survival (OS) rates for 1 year and 5 years were calculated as 74% and 36%, respectively. Extent of the primary tumor (P=.010), nodal spread (P=.009), and age (P=.004) significantly reduced the OS. Disease-free survival (DFS) was significantly reduced by age (P=.003), extent of the primary (P=.006), nodal (P=.004), and hematogenous (P=.048) spread. Multimodal therapy including surgery improved the OS and DFS rates (P<.05). ConclusionPrognosis is poor due to late disease recognition. However, multimodal therapeutic regimens, including surgery, may improve the outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kauke, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-184103
DOI:	10.1002/hed.25108
Journal or Publication Title:	Head Neck-J. Sci. Spec. Head Neck
Volume:	40
Number:	6
Page Range:	S. 1279 - 1287
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0347
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOFT-TISSUE SARCOMAS; PROGNOSTIC-FACTORS; NASAL CAVITY; HEAD; NECK; MANAGEMENT; FEATURES; OUTCOMES Multiple languages Otorhinolaryngology; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18410