Universität zu Köln

Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Grosveld, Frank G. and Papantonis, Argyris ORCID: 0000-0001-7551-1073 (2018). Forces driving the three-dimensional folding of eukaryotic genomes. Mol. Syst. Biol., 14 (6). HOBOKEN: WILEY. ISSN 1744-4292

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Abstract

The last decade has radically renewed our understanding of higher order chromatin folding in the eukaryotic nucleus. As a result, most current models are in support of a mostly hierarchical and relatively stable folding of chromosomes dividing chromosomal territories into A- (active) and B- (inactive) compartments, which are then further partitioned into topologically associating domains (TADs), each of which is made up from multiple loops stabilized mainly by the CTCF and cohesin chromatin-binding complexes. Nonetheless, the structure-to-function relationship of eukaryotic genomes is still not well understood. Here, we focus on recent work highlighting the biophysical and regulatory forces that contribute to the spatial organization of genomes, and we propose that the various conformations that chromatin assumes are not so much the result of a linear hierarchy, but rather of both converging and conflicting dynamic forces that act on it.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rada-Iglesias, Alvaro UNSPECIFIED orcid.org/0000-0001-7137-1341 UNSPECIFIED Grosveld, Frank G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papantonis, Argyris UNSPECIFIED orcid.org/0000-0001-7551-1073 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-184352
DOI:	10.15252/msb.20188214
Journal or Publication Title:	Mol. Syst. Biol.
Volume:	14
Number:	6
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1744-4292
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EMBRYONIC STEM-CELLS; TOPOLOGICALLY ASSOCIATING DOMAINS; TRANSCRIPTION FACTOR-BINDING; 3D CHROMATIN ORGANIZATION; RNA-POLYMERASE-II; HI-C REVEALS; LOOP EXTRUSION; PHASE-SEPARATION; GENE-REGULATION; LINEAGE COMMITMENT Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18435