Universität zu Köln

Pierot, Laurent, Moret, Jacques, Barreau, Xavier, Szikora, Istvan, Herbreteau, Denis, Turjman, Francis, Holtmannspotter, Markus, Januel, Anne-Christine, Costalat, Vincent, Fiehler, Jens, Klisch, Joachim, Gauvrit, Jean-Yves, Weber, Werner, Desal, Hubert ORCID: 0000-0002-4665-1461, Velasco, Stephane, Liebig, Thomas, Stockx, Luc, Berkefeld, Joachim, Molyneux, Andrew, Byrne, James and Spelle, Laurent (2018). Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series. J. NeuroInterventional Surg., 10 (6). S. 553 - 560. LONDON: BMJ PUBLISHING GROUP. ISSN 1759-8486

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Abstract

BackgroundFlow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.PurposeTo report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.MethodsWEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.ResultsThe cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.510.2 years). Aneurysm locations were middle cerebral artery in 86/169 aneurysms (50.9%), anterior communicating artery in 36/169 (21.3%), basilar artery in 30/169 (17.8%), and internal carotid artery terminus in 17/169 (10.1%). The aneurysm was ruptured in 14/169 (8.3%). There was no mortality at 1month and procedure/device-related morbidity was 1.2% (2/168). At 1year, complete aneurysm occlusion was observed in 81/153 aneurysms (52.9%), neck remnant in 40/153 aneurysms (26.1%), and aneurysm remnant in 32/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.ConclusionsThis series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment.Clinical trial registrationFrench Observatory: Unique identifier (NCT18069); WEBCAST and WEBCAST-2: Unique identifier (NCT01778322).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pierot, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED Moret, Jacques UNSPECIFIED UNSPECIFIED UNSPECIFIED Barreau, Xavier UNSPECIFIED UNSPECIFIED UNSPECIFIED Szikora, Istvan UNSPECIFIED UNSPECIFIED UNSPECIFIED Herbreteau, Denis UNSPECIFIED UNSPECIFIED UNSPECIFIED Turjman, Francis UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtmannspotter, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Januel, Anne-Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Costalat, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiehler, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Klisch, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauvrit, Jean-Yves UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Desal, Hubert UNSPECIFIED orcid.org/0000-0002-4665-1461 UNSPECIFIED Velasco, Stephane UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebig, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Stockx, Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkefeld, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Molyneux, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Byrne, James UNSPECIFIED UNSPECIFIED UNSPECIFIED Spelle, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185010
DOI:	10.1136/neurintsurg-2017-013448
Journal or Publication Title:	J. NeuroInterventional Surg.
Volume:	10
Number:	6
Page Range:	S. 553 - 560
Date:	2018
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1759-8486
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNRUPTURED INTRACRANIAL ANEURYSMS; BARE PLATINUM COILS; ENDOVASCULAR TREATMENT; BIFURCATION ANEURYSMS; FLOW-DISRUPTION; TRIAL; COMPLICATIONS; FEASIBILITY; MANAGEMENT; OUTCOMES Multiple languages Neuroimaging; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18501