Universität zu Köln

Nestler, Tim, Huber, Johannes ORCID: 0000-0001-7243-8958, Laury, Adrienne M., Isbarn, Hendrik, Heidenreich, Axel, Schmelz, Hans U. and Ruf, Christian G. (2018). Thromboprophylaxis and the route of administration of chemotherapy in testicular cancer patients in German-speaking countries. World J. Urol., 36 (6). S. 913 - 921. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Due to the excellent cure rates for testicular cancer (TC), focus has shifted towards decreasing therapy-related morbidities. Thrombosis is a frequent complication of cisplatin chemotherapy. Furthermore, the optimal route of administration for chemotherapy is still under debate. The purpose of this study was to assess the patterns of care concerning dosing and duration of thromboprophylaxis currently utilized in TC patients in German-speaking countries as well as the route of chemotherapy administration. A standardized questionnaire was sent to all members of the German TC Study Group (GTCSG) and to all the urological university hospitals in Germany. The questionnaire was also sent to the oncologic clinics at those universities where urologists do not administer chemotherapy. The response rate was 87% (55/63). Prophylactic anticoagulation with low-molecular-weight heparin (LMWH) was administered in 94% of the clinics. The dosing of LMWH was prophylactic (85%), high prophylactic (adjusted to bodyweight) (7%), or risk adapted (9%). After completion of chemotherapy, anticoagulation was continued in 15 clinics (33%) for 2 to 24 weeks, while the remainder stopped the LMWH upon cessation of chemotherapy. Chemotherapy was administered via central venous access in 59%, peripheral IV in 27%, or both in 14% of the clinics. Most of the institutions performed some form of thromboprophylaxis, although the modes of application varied by institution type and amongst the urologists and oncologists. Prospective studies are needed to evaluate the incidence, date of occurrence, and risk factors of venous thrombosis during TC chemotherapy to provide a recommendation concerning prophylactic anticoagulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nestler, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Johannes UNSPECIFIED orcid.org/0000-0001-7243-8958 UNSPECIFIED Laury, Adrienne M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbarn, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmelz, Hans U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruf, Christian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185468
DOI:	10.1007/s00345-018-2222-x
Journal or Publication Title:	World J. Urol.
Volume:	36
Number:	6
Page Range:	S. 913 - 921
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-8726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CISPLATIN-BASED CHEMOTHERAPY; VENOUS ACCESS PORTS; THROMBOEMBOLIC EVENTS; CELL CANCER; TUMORS; COMPLICATIONS; THROMBOSIS; POLYCHEMOTHERAPY; PROPHYLAXIS; PREVENTION Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18546