Universität zu Köln

Stroethoff, Martin, Behmenburg, Friederike, Spittler, Kerstin, Raupach, Annika, Heinen, Andre, Hollmann, Markus W., Huhn, Ragnar and Mathes, Alexander (2018). Activation of Melatonin Receptors by Ramelteon Induces Cardioprotection by Postconditioning in the Rat Heart. Anesth. Analg., 126 (6). S. 2112 - 2116. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 0003-2999

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Abstract

Activation of melatonin receptors protects the heart against ischemia-reperfusion injury. Ramelteon, a clinically used drug for insomnia, acts via activation of melatonin receptors. We investigated whether ramelteon induces acute infarct size reduction by postconditioning. Male Wistar rats were randomized to 6 groups. Hearts were treated with melatonin and ramelteon at the beginning of reperfusion. The melatonin receptor inhibitor luzindole was administered with and without melatonin and ramelteon, respectively. Ramelteon reduced infarct size to the same extent as melatonin. Both effects were completely abolished by luzindole. The results show for the first time that ramelteon induces cardioprotection by postconditioning.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stroethoff, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Behmenburg, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Spittler, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Raupach, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinen, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Hollmann, Markus W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huhn, Ragnar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathes, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185486
DOI:	10.1213/ANE.0000000000002625
Journal or Publication Title:	Anesth. Analg.
Volume:	126
Number:	6
Page Range:	S. 2112 - 2116
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	0003-2999
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REPERFUSION INJURY; HEPATIC PERFUSION; HEMORRHAGIC-SHOCK; LIVER-FUNCTION; DRUGS Multiple languages Anesthesiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18548