Universität zu Köln

Schatton, Desiree and Rugarli, Elena I. ORCID: 0000-0002-5782-1067 (2018). Post-transcriptional regulation of mitochondrial function. Curr. Opin. Physiol., 3. S. 6 - 16. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 2468-8673

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Abstract

RNA-binding proteins (RBPs) can control each step of the mRNA life cycle, such as splicing, nuclear export, stability, degradation, localization, and translation efficiency. Thus, RBPs can modulate the final amount of protein level and play an important role in fine-tuning many cellular processes. Surprisingly, the role of specific RBPs to allow the dynamic and coordinated expression of functionally related mitochondrial proteins has begun to emerge only recently. These RBPs define specific post-transcriptional RNA regulons that fine-tune mitochondrial gene expression, thus tailoring the effects of broad transcriptional responses to specific demands or affecting mitochondrial biogenesis independently from de novo transcription. Moreover, a handful of RBPs promote translation of mitochondrial proteins in close proximity to the organelle. Here, we review the molecular components that play a role in these elaborate and flexible mechanisms, and discuss the physiological implications of post-transcriptional regulation for mitochondrial function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schatton, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Rugarli, Elena I. UNSPECIFIED orcid.org/0000-0002-5782-1067 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185600
DOI:	10.1016/j.cophys.2017.12.008
Journal or Publication Title:	Curr. Opin. Physiol.
Volume:	3
Page Range:	S. 6 - 16
Date:	2018
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	2468-8673
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RNA-BINDING PROTEINS; MESSENGER-RNA; OXIDATIVE-PHOSPHORYLATION; SACCHAROMYCES-CEREVISIAE; YEAST MITOCHONDRIA; GENE-EXPRESSION; CYTOCHROME-C; PUF FAMILY; TRANSLATION; LOCALIZATION Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18560