Universität zu Köln

Gotovina, Jelena ORCID: 0000-0003-1503-5276, Pranger, Christina L., Jensen, Annika N., Wagner, Stefanie, Kothgassner, Oswald D., Mothes-Luksch, Nadine, Palme, Rupert ORCID: 0000-0001-9466-3662, Larenas-Linnemann, Desiree, Singh, Jaswinder, Moesges, Ralph, Felnhofer, Anna ORCID: 0000-0002-0081-7489, Glenk, Lisa-Maria and Jensen-Jarolim, Erika (2018). Elevated oxytocin and noradrenaline indicate higher stress levels in allergic rhinitis patients: Implications for the skin prick diagnosis in a pilot study. PLoS One, 13 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background & Aims The effects of acute stress on allergic symptoms are little understood. The intention of this clinical study was to study the effects of acute stress and related mediators in allergic rhinitis (AR), taking the wheal and flare reaction in skin prick testing (SPT) as a readout. Methods 19 healthy and 21 AR patients were first subjected to SPTs with grass pollen-, birch pollen- and house dust mite allergen extracts, histamine and negative control. Subsequently, participants were exposed to a standardized Trier Social Stress Test (TSST), followed by SPT on the contralateral forearm. Stress responders were identified based on the salivary cortisol levels and State-subscale of State-Trait-Anxiety Inventory (STAI-S). Blood samples were collected before and after TSST and adrenaline, noradrenaline, serotonin, oxytocin, platelet activating factor and prostaglandin D2 were analyzed by enzyme immunoassay (EIA). Results SPT results of 14/21 allergics and 11/19 healthy who responded with stress after TSST were evaluated. No significant differences regarding SPT to allergens or histamine before and after the stress test could be calculated at the group level. But, the wheal and flare sizes after TSST increased or decreased substantially in several individuals, and unmasked sensitization in one healthy person, which could not be correlated with any mediator tested. The most significant finding, however, was that, independent of TSST, the baseline levels of oxytocin and noradrenaline were significantly higher in allergics. Conclusion High baseline levels of noradrenaline points toward higher stress levels in allergic patients, which might be counterregulated by elevated oxytocin. Moreover, our data indicate that acute stress may have a significant influence on SPT fidelity in susceptible individuals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gotovina, Jelena UNSPECIFIED orcid.org/0000-0003-1503-5276 UNSPECIFIED Pranger, Christina L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen, Annika N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kothgassner, Oswald D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mothes-Luksch, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Palme, Rupert UNSPECIFIED orcid.org/0000-0001-9466-3662 UNSPECIFIED Larenas-Linnemann, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Singh, Jaswinder UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Felnhofer, Anna UNSPECIFIED orcid.org/0000-0002-0081-7489 UNSPECIFIED Glenk, Lisa-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Jensen-Jarolim, Erika UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-185922
DOI:	10.1371/journal.pone.0196879
Journal or Publication Title:	PLoS One
Volume:	13
Number:	5
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORTISOL RESPONSES; PSYCHOLOGICAL STRESS; PSYCHOSOCIAL STRESS; MAST-CELLS; CLINICAL-RELEVANCE; ANXIETY; RELEASE; INFLAMMATION; AXIS; RESPONSIVENESS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18592