Universität zu Köln

Morozov, Vasily, Borkowski, Julia and Hanisch, Franz-Georg (2018). The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity. Molecules, 23 (5). BASEL: MDPI. ISSN 1420-3049

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Abstract

Epithelial human blood group antigens (HBGAs) on O-glycans play roles in pathogen binding and the initiation of infection, while similar structures on secretory mucins exert protective functions. These double-faced features of O-glycans in infection and innate immunity are reviewed based on two instructive examples of bacterial and viral pathogens. Helicobacter pylori represents a class 1 carcinogen in the human stomach. By expressing blood group antigen-binding adhesin (BabA) and LabA adhesins that bind to Lewis-b and LacdiNAc, respectively, H. pylori colocalizes with the mucin MUC5AC in gastric surface epithelia, but not with MUC6, which is cosecreted with trefoil factor family 2 (TFF2) by deep gastric glands. Both components of the glandular secretome are concertedly up-regulated upon infection. While MUC6 expresses GlcNAc-capped glycans as natural antibiotics for H. pylori growth control, TFF2 may function as a probiotic lectin. In viral infection human noroviruses of the GII genogroup interact with HBGAs via their major capsid protein, VP1. HBGAs on human milk oligosaccharides (HMOs) may exert protective functions by binding to the P2 domain pocket on the capsid. We discuss structural details of the P2 carbohydrate-binding pocket in interaction with blood group H/Lewis-b HMOs and fucoidan-derived oligofucoses as effective interactors for the most prevalent norovirus strains, GII.4 and GII.17.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morozov, Vasily UNSPECIFIED UNSPECIFIED UNSPECIFIED Borkowski, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanisch, Franz-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-187397
DOI:	10.3390/molecules23051151
Journal or Publication Title:	Molecules
Volume:	23
Number:	5
Date:	2018
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1420-3049
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD GROUP ANTIGENS; HELICOBACTER-PYLORI INFECTION; HUMAN-MILK OLIGOSACCHARIDES; TREFOIL FAMILY FACTOR-2; HUMAN GASTRIC MUCIN; NOROVIRUS GASTROENTERITIS; PERSISTENT INFECTION; BINDING SPECIFICITY; STRUCTURAL-ANALYSIS; EPOCHAL EVOLUTION Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18739