Peitz, Michael, Bechler, Tamara, Thiele, Catrin Cornelia, Veltel, Monika, Bloschies, Melanie, Fliessbach, Klaus, Ramirez, Alfredo ORCID: 0000-0003-4991-763X and Bruestle, Oliver (2018). Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE kappa 4/epsilon 4 genotype. Stem Cell Res., 29. S. 250 - 254. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1876-7753

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Abstract

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE epsilon 4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE epsilon 4/epsilon 4 allele.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Peitz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechler, TamaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, Catrin CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veltel, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bloschies, MelanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Bruestle, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-187484
DOI: 10.1016/j.scr.2018.04.011
Journal or Publication Title: Stem Cell Res.
Volume: 29
Page Range: S. 250 - 254
Date: 2018
Publisher: ELSEVIER SCIENCE BV
Place of Publication: AMSTERDAM
ISSN: 1876-7753
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18748

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