Universität zu Köln

Balaji, Vishnu, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2018). Ubiquitylation Pathways In Insulin Signaling and Organismal Homeostasis. Bioessays, 40 (5). HOBOKEN: WILEY. ISSN 1521-1878

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Abstract

The insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) pathway is a pivotal genetic program regulating cell growth, tissue development, metabolic physiology, and longevity of multicellular organisms. IIS integrates a fine-tuned cascade of signaling events induced by insulin/IGF-1, which is precisely controlled by post-translational modifications. The ubiquitin/proteasome-system (UPS) influences the functionality of IIS through inducible ubiquitylation pathways that regulate internalization of the insulin/IGF-1 receptor, the stability of downstream insulin/IGF-1 signaling targets, and activity of nuclear receptors for control of gene expression. An age-related decline in UPS activity is often associated with an impairment of IIS, contributing to pathologies such as cancer, diabetes, cardiovascular, and neurodegenerative disorders. Recent findings identified a key role of diverse ubiquitin modifications in insulin signaling decisions, which governs dynamic adaption upon environmental and physiological changes. In this review, we discuss the mutual crosstalk between ubiquitin and insulin signaling pathways in the context of cellular and organismal homeostasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balaji, Vishnu UNSPECIFIED UNSPECIFIED UNSPECIFIED Pokrzywa, Wojciech UNSPECIFIED orcid.org/0000-0002-5110-4462 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-188582
DOI:	10.1002/bies.201700223
Journal or Publication Title:	Bioessays
Volume:	40
Number:	5
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1521-1878
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-I; E3 UBIQUITIN LIGASE; PROTEIN-TYROSINE-PHOSPHATASE; HEAT-SHOCK PROTEINS; RECEPTOR SUBSTRATE-1; MEDIATED DEGRADATION; OXIDATIVE STRESS; PROTEASOMAL DEGRADATION; CAENORHABDITIS-ELEGANS; TUMOR SUPPRESSION Multiple languages Biochemistry & Molecular Biology; Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/18858