Santoro, Nicole, Labopin, Myriam, Giannotti, Federica, Ehninger, Gerard, Niederwieser, Dietger, Brecht, Arne, Stelljes, Matthias, Kroeger, Nicolaus, Einsele, Herman, Eder, Matthias, Hallek, Michael, Glass, Bertram, Finke, Juergen, Ciceri, Fabio, Mohty, Mohamad, Ruggeri, Annalisa and Nagler, Arnon (2018). Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT. J. Hematol. Oncol., 11. LONDON: BIOMED CENTRAL LTD. ISSN 1756-8722

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Abstract

Background: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. Methods: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients >= 60 years. Results: Median follow-up was 23 months. Disease status at transplant differs significantly between the two groups (p < 10(-4)). Reduced intensity conditioning (RIC) was administrated to 73 and 77% of Haplo and MUD, respectively (p = 0.23). Stem cell source was the bone marrow (BM) in 52% of the Haplo and 6% of MUD (p < 10(-4)). Anti-thymocyte globulin (ATG) was most frequently used in MUD (p < 10(-4)) while post-Tx cyclophosphamide (PT-Cy) was given in 62% of Haplo. Engraftment was achieved in 90% of the Haplo vs 97% of MUD (p < 10(-4)). In multivariate analysis, no significant difference was found between Haplo and MUD for acute (a) graft versus host disease (GVHD) grade II-IV, relapse incidence (RI), non-relapse mortality (NRM), leukemia free survival (LFS), graft-versus-host-free-relapse free survival (GRFS), and overall survival (OS). Extensive chronic (c) GVHD was significantly higher for MUD as compared to Haplo (HR 2, p = 0.01, 95% CI 1.17-3.47). A propensity score analysis confirmed the higher risk of extensive cGVHD for MUD without differences for other outcomes. Conclusions: Allo-SCT from both Haplo and MUD are valid option for AML patients >= 60 years of age with similar results. Transplantation from MUD was associated with higher extensive cGVHD. Our findings suggest that Haplo is a suitable and attractive graft source for patients >= 60 with AML in need of allo-SCT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Santoro, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Labopin, MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giannotti, FedericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehninger, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niederwieser, DietgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brecht, ArneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stelljes, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, NicolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Einsele, HermanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eder, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glass, BertramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finke, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ciceri, FabioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohty, MohamadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruggeri, AnnalisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nagler, ArnonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-189263
DOI: 10.1186/s13045-018-0598-0
Journal or Publication Title: J. Hematol. Oncol.
Volume: 11
Date: 2018
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1756-8722
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BONE-MARROW-TRANSPLANTATION; 1ST COMPLETE REMISSION; VERSUS-HOST-DISEASE; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; MYELODYSPLASTIC SYNDROME; ELDERLY-PATIENTS; SIBLING DONORS; ADULTS; OUTCOMES; BLOODMultiple languages
Oncology; HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18926

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