Winterer, G., Androsova, G., Bender, O., Boraschi, D., Borchers, F., Dschietzig, T. B., Feinkohl, I., Fletcher, P., Gallinat, J., Hadzidiakos, D., Haynes, J. D., Heppner, F., Hetzer, S., Hendrikse, J., Ittermann, B., Kant, I. M. J., Kraft, A., Krannich, A., Krause, R., Kuhn, S., Lachmann, G., van Montfort, S. J. T., Muller, A., Nurnberg, P., Ofosu, K., Pietsch, M., Pischon, T., Preller, J., Renzulli, E., Scheurer, K., Schneider, R., Slooter, A. J. C., Spies, C., Stamatakis, E., Volk, H. D., Weber, S., Wolf, A., Yurek, F. and Zacharias, N. (2018). Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project. Eur. Psychiat., 50. S. 34 - 40. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1778-3585

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Abstract

Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions - particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost-benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation. (C) 2017 Published by Elsevier Masson SAS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Winterer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Androsova, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bender, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boraschi, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borchers, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dschietzig, T. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feinkohl, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallinat, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hadzidiakos, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, J. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heppner, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hetzer, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hendrikse, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ittermann, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kant, I. M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraft, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krannich, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krause, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuhn, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lachmann, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Montfort, S. J. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nurnberg, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ofosu, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pietsch, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pischon, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preller, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renzulli, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheurer, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slooter, A. J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spies, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stamatakis, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volk, H. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yurek, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zacharias, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-189937
DOI: 10.1016/j.eurpsy.2017.10.004
Journal or Publication Title: Eur. Psychiat.
Volume: 50
Page Range: S. 34 - 40
Date: 2018
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication: ISSY-LES-MOULINEAUX
ISSN: 1778-3585
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WHITE-MATTER HYPERINTENSITIES; CARE-UNIT SURVIVORS; DELIRIUM DURATION; BRAIN ATROPHY; INFLAMMATION; COHORT; ASSOCIATION; PATHOLOGY; SURGERY; RESERVEMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18993

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