Universität zu Köln

Sadda, Srinivas R., Guymer, Robyn ORCID: 0000-0002-9441-4356, Holz, Frank G., Schmitz-Valckenberg, Steffen, Curcio, Christine A., Bird, Alan C., Blodi, Barbara A., Bottoni, Ferdinando, Chakravarthy, Usha ORCID: 0000-0002-2606-3734, Chew, Emily Y., Csaky, Karl, Danis, Ronald P., Fleckenstein, Monika ORCID: 0000-0001-8321-8037, Freund, K. Bailey ORCID: 0000-0002-7888-9773, Grunwald, Juan ORCID: 0000-0002-5973-6616, Hoyng, Carel B., Jaffe, Glenn J., Liakopoulos, Sandra, Mones, Jordi M., Pauleikhoff, Daniel, Rosenfeld, Philip J., Sarraf, David, Spaide, Richard F., Tadayoni, Ramin ORCID: 0000-0001-5616-3579, Tufail, Adnan, Wolf, Sebastian ORCID: 0000-0002-7467-7028 and Staurenghi, Giovanni ORCID: 0000-0002-2299-5251 (2018). Consensus Definition for Atrophy Associated with Age-Related Macular Degeneration on OCT Classification of Atrophy Report 3. Ophthalmology, 125 (4). S. 537 - 549. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1549-4713

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Abstract

Purpose: To develop consensus terminology and criteria for defining atrophy based on OCT findings in the setting of age-related macular degeneration (AMD). Design: Consensus meeting. Participants: Panel of retina specialists, image reading center experts, retinal histologists, and optics engineers. Methods: As part of the Classification of Atrophy Meetings (CAM) program, an international group of experts surveyed the existing literature, performed a masked analysis of longitudinal multimodal imaging for a series of eyes with AMD, and reviewed the results of this analysis to define areas of agreement and disagreement. Through consensus discussions at 3 meetings over 12 months, a classification system based on OCT was proposed for atrophy secondary to AMD. Specific criteria were defined to establish the presence of atrophy. Main Outcome Measures: A consensus classification system for atrophy and OCT-based criteria to identify atrophy. Results: OCT was proposed as the reference standard or base imaging method to diagnose and stage atrophy. Other methods, including fundus autofluorescence, near-infrared reflectance, and color imaging, provided complementary and confirmatory information. Recognizing that photoreceptor atrophy can occur without retinal pigment epithelium (RPE) atrophy and that atrophy can undergo an evolution of different stages, 4 terms and histologic candidates were proposed: complete RPE and outer retinal atrophy (cRORA), incomplete RPE and outer retinal atrophy, complete outer retinal atrophy, and incomplete outer retinal atrophy. Specific OCT criteria to diagnose cRORA were proposed: (1) a region of hypertransmission of at least 250 mu m in diameter, (2) a zone of attenuation or disruption of the RPE of at least 250 mu m in diameter, (3) evidence of overlying photoreceptor degeneration, and (4) absence of scrolled RPE or other signs of an RPE tear. Conclusions: A classification system and criteria for OCT-defined atrophy in the setting of AMD has been proposed based on an international consensus. This classification is a more complete representation of changes that occur in AMD than can be detected using color fundus photography alone. Longitudinal information is required to validate the implied risk of vision loss associated with these terms. This system will enable such future studies to be undertaken using consistent definitions. (C) 2017 by the American Academy of Ophthalmology

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sadda, Srinivas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guymer, Robyn UNSPECIFIED orcid.org/0000-0002-9441-4356 UNSPECIFIED Holz, Frank G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz-Valckenberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Curcio, Christine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bird, Alan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blodi, Barbara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bottoni, Ferdinando UNSPECIFIED UNSPECIFIED UNSPECIFIED Chakravarthy, Usha UNSPECIFIED orcid.org/0000-0002-2606-3734 UNSPECIFIED Chew, Emily Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Csaky, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Danis, Ronald P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleckenstein, Monika UNSPECIFIED orcid.org/0000-0001-8321-8037 UNSPECIFIED Freund, K. Bailey UNSPECIFIED orcid.org/0000-0002-7888-9773 UNSPECIFIED Grunwald, Juan UNSPECIFIED orcid.org/0000-0002-5973-6616 UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaffe, Glenn J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Mones, Jordi M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauleikhoff, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenfeld, Philip J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarraf, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Spaide, Richard F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tadayoni, Ramin UNSPECIFIED orcid.org/0000-0001-5616-3579 UNSPECIFIED Tufail, Adnan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Sebastian UNSPECIFIED orcid.org/0000-0002-7467-7028 UNSPECIFIED Staurenghi, Giovanni UNSPECIFIED orcid.org/0000-0002-2299-5251 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-190177
DOI:	10.1016/j.ophtha.2017.09.028
Journal or Publication Title:	Ophthalmology
Volume:	125
Number:	4
Page Range:	S. 537 - 549
Date:	2018
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1549-4713
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; SUBRETINAL DRUSENOID DEPOSITS; GEOGRAPHIC ATROPHY; FUNDUS AUTOFLUORESCENCE; PREDICTIVE-VALUE; GRADING SYSTEM; END-POINTS; MACULOPATHY; PROGRESSION; GROWTH Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19017