Universität zu Köln

Kobe, Carsten, Baues, Christian, Fuchs, Michael, Drzezga, Alexander, Borchmann, Peter and Dietlein, Markus (2018). Positron emission tomography in Hodgkin's lymphoma. Onkologe, 24 (4). S. 287 - 295. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

The FDG-PET method is a standard procedure in staging and response assessment of Hodgkin's lymphoma patients. An accurate staging allows the bone marrow biopsy to be omitted if PET is negative concerning bone marrow involvement. An FDG-PET after induction therapy provides additional relevant prognostic information. The FDG-PET adapted therapy regimens have been introduced making use of the high predictive value of FDG PET early in the treatment course, e.aEurog. after two cycles of chemotherapy. Success rates of treatment could be improved for both intensification and de-escalation of treatment on the basis of PET performed after two cycles of chemotherapy. In the case of a negative PET after two cycles of effective chemotherapy for advanced stages, chemotherapy can be restricted to a total of 4 cycles instead of 6 cycles. Furthermore, radiotherapy in advanced stages can be safely omitted in PET negative patients after effective chemotherapy. The reliability of end of treatment PET as a basis for omitting radiotherapy in early and intermediate stages of Hodgkin's lymphoma is probably given, but remains to be documented. Robust and reproducible interpretation criteria are being used both in ongoing clinical trials and in the daily routine. The recommended five-point Deauville scale has become the standard in assessment of the response to PET treatment, with the caveat that the consequences of a PET scan may be influenced by previous and subsequent treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kobe, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Baues, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-191854
DOI:	10.1007/s00761-018-0341-z
Journal or Publication Title:	Onkologe
Volume:	24
Number:	4
Page Range:	S. 287 - 295
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESPONSE ASSESSMENT; EARLY RELAPSE; PET; CHEMOTHERAPY; RADIOTHERAPY; DISEASE; REDUCTION; THERAPY; TRIAL; NEED Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19185