Schrijver, Lieske H., Olsson, Hakan ORCID: 0000-0002-8794-9635, Phillips, Kelly-Anne, Terry, Mary Beth, Goldgar, David E., Kast, Karin, Engel, Christoph ORCID: 0000-0002-7247-282X, Mooij, Thea M., Adlard, Julian, Barrowdale, Daniel, Davidson, Rosemarie, Eeles, Ros, Ellis, Steve, Evans, D. Gareth, Frost, Debra, Izatt, Louise, Porteous, Mary E., Side, Lucy E., Walker, Lisa, Berthet, Pascaline, Bonadona, Val Erie, Leroux, Dominique, Mouret-Fourme, Emmanuelle, Venat-Bouvet, Laurence, Buys, Saundra S., Southey, Melissa C., John, Esther M., Chung, Wendy K., Daly, Mary B., Bane, Anita, van Asperen, Christi J., Garcia, Encarna B. Gomez, Mourits, Marian J. E., Roos-Blom, Marie-Jose ORCID: 0000-0003-4066-607X, Friedlander, Michael L., McLachlan, Sue-Anne, Singer, Christian F., Foretova, Lenka, Gerdes, Anne-Marie, Caldes, Trinidad, Olah, Edith, Jakubowska, Anna, Nogues, Catherine, Andrieu, Nadine, Easton, Douglas F., van Leeuwen, Flora E., Hopper, John L., Milne, Roger L., Antoniou, Antonis C., Rookus, Matti A., Rookus, M. A., Hogervorst, F. B. L., van Leeuwen, F. E., Adank, M. A., Schmidt, M. K., Russell, N. S., de Lange, J. L., Wijnands, R., Jenner, D. J., Collee, J. M., van den Ouweland, A. M. W., Hooning, M. J., Seynaeve, C., van Deurzen, C. H. M., Obdeijn, I. M., van Asperen, C. J., Wijnen, J. T., Tollenaar, R. A. E. M., Devilee, P., van Cronenburg, T. C. T. E. F., Kets, C. M., Mensenkamp, A. R., Ausems, M. G. E. M., van der Luijt, R. B., van der Pol, C. C., Aalfs, C. M., Meijers-Heijboer, H. E. J., van Os, T. A. M., van Engelen, K., Gille, J. J. P., Waisfisz, Q., Gomez-Garcia, E. B., Blok, M. J., Oosterwijk, J. C., van der Hout, A. H., Mourits, M. J., de Bock, G. H., Siesling, S., Verloop, J. and Overbeek, L. I. H. (2018). Oral Contraceptive Use and Breast Cancer Risk: Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study. JNCI Cancer Spectr., 2 (2). OXFORD: OXFORD UNIV PRESS. ISSN 2515-5091

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Abstract

Background: For BRCA1 and BRCA2 mutation carriers, the association between oral contraceptive preparation (OCP) use and breast cancer (BC) risk is still unclear. Methods: Breast camcer risk associations were estimated from OCP data on 6030 BRCA1 and 3809 BRCA2 mutation carriers using age-dependent Cox regression, stratified by study and birth cohort. Prospective, left-truncated retrospective and full-cohort retrospective analyses were performed. Results: For BRCA1 mutation carriers, OCP use was not associated with BC risk in prospective analyses (hazard ratio [HR] = 1.08, 95% confidence interval [CI] = 0.75 to 1.56), but in the left-truncated and full-cohort retrospective analyses, risks were increased by 26% (95% CI = 6% to 51%) and 39% (95% CI = 23% to 58%), respectively. For BRCA2 mutation carriers, OCP use was associated with BC risk in prospective analyses (HR = 1.75, 95% CI = 1.03 to 2.97), but retrospective analyses were inconsistent (left-truncated: HR = 1.06, 95% CI = 0.85 to 1.33; full cohort: HR = 1.52, 95% CI = 1.28 to 1.81). There was evidence of increasing risk with duration of use, especially before the first full-term pregnancy (BRCA1: both retrospective analyses, P < .001 and P = .001, respectively; BRCA2: full retrospective analysis, P = .002). Conclusions: Prospective analyses did not show that past use of OCP is associated with an increased BC risk for BRCA1 mutation carriers in young middle-aged women (40-50 years). For BRCA2 mutation carriers, a causal association is also not likely at those ages. Findings between retrospective and prospective analyses were inconsistent and could be due to survival bias or a true association for younger women who were underrepresented in the prospective cohort. Given the uncertain safety of long-term OCP use for BRCA1/2 mutation carriers, indications other than contraception should be avoided and non-hormonal contraceptive methods should be discussed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schrijver, Lieske H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olsson, HakanUNSPECIFIEDorcid.org/0000-0002-8794-9635UNSPECIFIED
Phillips, Kelly-AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terry, Mary BethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Mooij, Thea M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adlard, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davidson, RosemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellis, SteveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frost, DebraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porteous, Mary E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Side, Lucy E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berthet, PascalineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonadona, Val ErieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leroux, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mouret-Fourme, EmmanuelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venat-Bouvet, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chung, Wendy K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daly, Mary B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bane, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, Christi J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia, Encarna B. GomezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, Marian J. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roos-Blom, Marie-JoseUNSPECIFIEDorcid.org/0000-0003-4066-607XUNSPECIFIED
Friedlander, Michael L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McLachlan, Sue-AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foretova, LenkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerdes, Anne-MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olah, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakubowska, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogues, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrieu, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, Flora E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopper, John L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milne, Roger L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, Matti A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hogervorst, F. B. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Leeuwen, F. E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adank, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, M. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, N. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Lange, J. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wijnands, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenner, D. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collee, J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Ouweland, A. M. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooning, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seynaeve, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Deurzen, C. H. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obdeijn, I. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, C. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wijnen, J. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tollenaar, R. A. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Cronenburg, T. C. T. E. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kets, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mensenkamp, A. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, M. G. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Luijt, R. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Pol, C. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aalfs, C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meijers-Heijboer, H. E. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, T. A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Engelen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gille, J. J. P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waisfisz, Q.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez-Garcia, E. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blok, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oosterwijk, J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Hout, A. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourits, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Bock, G. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siesling, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verloop, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Overbeek, L. I. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-192042
DOI: 10.1093/jncics/pky023
Journal or Publication Title: JNCI Cancer Spectr.
Volume: 2
Number: 2
Date: 2018
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 2515-5091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OVARIAN-CANCER; WOMEN; CONSORTIUM; PREVENTION; KCONFABMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19204

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