Universität zu Köln

Mellinghoff, Sibylle C., Bassetti, Matteo ORCID: 0000-0002-0145-9740, Doerfel, Daniela, Hagel, Stefan ORCID: 0000-0003-2999-6131, Lehners, Nicola, Plis, Andrzej, Schalk, Enrico ORCID: 0000-0003-1892-5098, Vena, Antonio ORCID: 0000-0002-0697-3992 and Cornely, Oliver A. (2018). Isavuconazole shortens the QTc interval. Mycoses, 61 (4). S. 256 - 261. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Isavuconazole is a novel antifungal drug approved for the treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. The objective of the study was to describe changes in the QTc interval induced by isavuconazole treatment. A total of 26 adult patients from 7 hospitals were included. Patients received isavuconazole for the treatment of invasive fungal infection and, in 1 case, for prophylaxis due to QTc prolongation under fluconazole. Twelve-channel electrocardiograms (ECGs) were performed before and during treatment. Out of 26 patients, 24 showed shortening of QTc interval. In patients with QTc shortening, QTc during isavuconazole treatment showed a mean decrease of 7.4 +/- 5.8% (36.5 +/- 38.8ms, range 7-202; P=.004), compared to pre-isavuconazole ECG. One patient with available long-term follow-up showed further decrease in QTc on days 55 and 110. Apart from 1 case report, these are the first data outside controlled clinical trials showing QTc shortening. Knowledge about cardiac effects of isavuconazole will serve to better manage the use of concomitant medications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bassetti, Matteo UNSPECIFIED orcid.org/0000-0002-0145-9740 UNSPECIFIED Doerfel, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagel, Stefan UNSPECIFIED orcid.org/0000-0003-2999-6131 UNSPECIFIED Lehners, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Plis, Andrzej UNSPECIFIED UNSPECIFIED UNSPECIFIED Schalk, Enrico UNSPECIFIED orcid.org/0000-0003-1892-5098 UNSPECIFIED Vena, Antonio UNSPECIFIED orcid.org/0000-0002-0697-3992 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192094
DOI:	10.1111/myc.12731
Journal or Publication Title:	Mycoses
Volume:	61
Number:	4
Page Range:	S. 256 - 261
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DE-POINTES; LONG; VORICONAZOLE; PATIENT Multiple languages Dermatology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19209