Universität zu Köln

Rieckher, Matthias ORCID: 0000-0002-1945-9474, Bujarrabal, Arturo, Doll, Markus A., Soltanmohammadi, Najmeh and Schumacher, Bjoern (2018). A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes. J. Cell. Physiol., 233 (4). S. 2781 - 2791. HOBOKEN: WILEY. ISSN 1097-4652

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Abstract

The genetic information is constantly challenged by genotoxic attacks. DNA repair mechanisms evolved early in evolution and recognize and remove the various lesions. A complex network of DNA damage responses (DDR) orchestrates a variety of physiological adaptations to the presence of genome instability. Erroneous repair or malfunctioning of the DDR causes cancer development and the accumulation of DNA lesions drives the aging process. For understanding the complex DNA repair and DDR mechanisms it is pivotal to employ simple metazoan as model systems. The nematode Caenorhabditis elegans has become a well-established and popular experimental organism that allows dissecting genome stability mechanisms in dynamic and differentiated tissues and under physiological conditions. We provide an overview of the distinct advantages of the nematode system for studying DDR and provide a range of currently applied methodologies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rieckher, Matthias UNSPECIFIED orcid.org/0000-0002-1945-9474 UNSPECIFIED Bujarrabal, Arturo UNSPECIFIED UNSPECIFIED UNSPECIFIED Doll, Markus A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Soltanmohammadi, Najmeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192281
DOI:	10.1002/jcp.25979
Journal or Publication Title:	J. Cell. Physiol.
Volume:	233
Number:	4
Page Range:	S. 2781 - 2791
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-4652
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOUBLE-STRAND BREAK; NUCLEOTIDE EXCISION-REPAIR; C. ELEGANS; INDUCED APOPTOSIS; CELL-DEATH; MECHANISMS; LONGEVITY; REPLICATION; GERMLINE; MUTANTS Multiple languages Cell Biology; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19228