Universität zu Köln

Mutte, Sumanth K., Kato, Hirotaka ORCID: 0000-0002-8521-1450, Rothfels, Carl ORCID: 0000-0002-6605-1770, Melkonian, Michael, Wong, Gane Ka-Shu and Weijers, Dolf ORCID: 0000-0003-4378-141X (2018). Origin and evolution of the nuclear auxin response system. eLife, 7. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

The small signaling molecule auxin controls numerous developmental processes in land plants, acting mostly by regulating gene expression. Auxin response proteins are represented by large families of diverse functions, but neither their origin nor their evolution is understood. Here, we use a deep phylogenomics approach to reconstruct both the origin and the evolutionary trajectory of all nuclear auxin response protein families. We found that, while all subdomains are ancient, a complete auxin response mechanism is limited to land plants. Functional phylogenomics predicts defined steps in the evolution of response system properties, and comparative transcriptomics across six ancient lineages revealed how these innovations shaped a sophisticated response mechanism. Genetic analysis in a basal land plant revealed unexpected contributions of ancient non-canonical proteins in auxin response as well as auxin-unrelated function of core transcription factors. Our study provides a functional evolutionary framework for understanding diverse functions of the auxin signal.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mutte, Sumanth K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kato, Hirotaka UNSPECIFIED orcid.org/0000-0002-8521-1450 UNSPECIFIED Rothfels, Carl UNSPECIFIED orcid.org/0000-0002-6605-1770 UNSPECIFIED Melkonian, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wong, Gane Ka-Shu UNSPECIFIED UNSPECIFIED UNSPECIFIED Weijers, Dolf UNSPECIFIED orcid.org/0000-0003-4378-141X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-192391
DOI:	10.7554/eLife.33399
Journal or Publication Title:	eLife
Volume:	7
Date:	2018
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BOX PROTEIN TIR1; PATTERN-FORMATION; GENE FAMILY; EXPRESSION; PLANTS; LAND; ROOT; TRANSCRIPTION; ENDOCYTOSIS; PERCEPTION Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19239