Oparil, Suzanne, Acelajado, Maria Czarina ORCID: 0000-0002-1607-6136, Bakris, George L., Berlowitz, Dan R., Cifkova, Renata, Dominiczak, Anna F., Grassi, Guido, Jordan, Jens, Poulter, Neil R., Rodgers, Anthony ORCID: 0000-0003-1282-1896 and Whelton, Paul K. (2018). Hypertension. Nat. Rev. Dis. Primers, 4. LONDON: NATURE PUBLISHING GROUP. ISSN 2056-676X

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Abstract

Systemic arterial hypertension is the most important modifiable risk factor for all-cause morbidity and mortality worldwide and is associated with an increased risk of cardiovascular disease (CVD). Fewer than half of those with hypertension are aware of their condition, and many others are aware but not treated or inadequately treated, although successful treatment of hypertension reduces the global burden of disease and mortality. The aetiology of hypertension involves the complex interplay of environmental and pathophysiological factors that affect multiple systems, as well as genetic predisposition. The evaluation of patients with hypertension includes accurate standardized blood pressure (BP) measurement, assessment of the patients' predicted risk of atherosclerotic CVD and evidence of target-organ damage, and detection of secondary causes of hypertension and presence of comorbidities (such as CVD and kidney disease). Lifestyle changes, including dietary modifications and increased physical activity, are effective in lowering BP and preventing hypertension and its CVD sequelae. Pharmacological therapy is very effective in lowering BP and in preventing CVD outcomes in most patients; first-line antihypertensive medications include angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, dihydropyridine calcium-channel blockers and thiazide diuretics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Oparil, SuzanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Acelajado, Maria CzarinaUNSPECIFIEDorcid.org/0000-0002-1607-6136UNSPECIFIED
Bakris, George L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berlowitz, Dan R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cifkova, RenataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominiczak, Anna F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grassi, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poulter, Neil R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodgers, AnthonyUNSPECIFIEDorcid.org/0000-0003-1282-1896UNSPECIFIED
Whelton, Paul K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-192541
DOI: 10.1038/nrdp.2018.14
Journal or Publication Title: Nat. Rev. Dis. Primers
Volume: 4
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2056-676X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
QUALITY-OF-LIFE; HIGH-BLOOD-PRESSURE; CARDIOVASCULAR RISK-FACTORS; SYMPATHETIC-NERVOUS-SYSTEM; CALCIUM-CHANNEL BLOCKERS; RESISTANT HYPERTENSION; EUROPEAN-SOCIETY; GLOBAL BURDEN; WEIGHT-LOSS; ANTIHYPERTENSIVE THERAPYMultiple languages
Medicine, General & InternalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19254

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