Universität zu Köln

Cowie, Martin R., Woehrle, Holger, Wegscheider, Karl, Vettorazzi, Eik ORCID: 0000-0002-3737-6402, Lezius, Susanne ORCID: 0000-0002-4832-4333, Koenig, Wolfgang, Weidemann, Frank, Smith, Gillian, Angermann, Christiane, d'Ortho, Marie-Pia, Erdmann, Erland, Levy, Patrick, Simonds, Anita K., Somers, Virend K., Zannad, Faiez and Teschler, Helmut (2018). Adaptive servo-ventilation for central sleep apnoea in systolic heart failure: results of the major substudy of SERVE-HF. Eur. J. Heart Fail., 20 (3). S. 536 - 545. HOBOKEN: WILEY. ISSN 1879-0844

Full text not available from this repository.

Abstract

Aims The SERVE-HF trial investigated the impact of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with systolic heart failure. A preplanned substudy was conducted to provide insight into mechanistic changes underlying the observed effects of ASV, including assessment of changes in left ventricular function, ventricular remodelling, and cardiac, renal and inflammatory biomarkers. Methods and results In a subset of the 1325 randomised patients, echocardiography, cardiac magnetic resonance imaging (cMRI) and biomarker analysis were performed at baseline, and 3 and 12 months. In secondary analyses, data for patients with baseline and 12-month values were evaluated; 312 patients participated in the substudy. The primary endpoint, change in echocardiographically determined left ventricular ejection fraction from baseline to 12months, did not differ significantly between the ASV and the control groups. There were also no significant between-group differences for changes in left ventricular dimensions, wall thickness, diastolic function or right ventricular dimensions and ejection fraction (echocardiography), and on cMRI (in small patient numbers). Plasma N-terminal pro B-type natriuretic peptide concentration decreased in both groups, and values were similar at 12 months. There were no significant between-group differences in changes in cardiac, renal and systemic inflammation biomarkers. Conclusion In patients with systolic heart failure and CSA, addition of ASV to guideline-based medical management had no statistically significant effect on cardiac structure and function, or on cardiac biomarkers, renal function and systemic inflammation over 12 months. The increased cardiovascular mortality reported in SERVE-HF may not be related to adverse remodelling or worsening heart failure.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cowie, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woehrle, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegscheider, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Vettorazzi, Eik UNSPECIFIED orcid.org/0000-0002-3737-6402 UNSPECIFIED Lezius, Susanne UNSPECIFIED orcid.org/0000-0002-4832-4333 UNSPECIFIED Koenig, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Weidemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Gillian UNSPECIFIED UNSPECIFIED UNSPECIFIED Angermann, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED d'Ortho, Marie-Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Erland UNSPECIFIED UNSPECIFIED UNSPECIFIED Levy, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Simonds, Anita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Somers, Virend K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zannad, Faiez UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschler, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-193332
DOI:	10.1002/ejhf.1048
Journal or Publication Title:	Eur. J. Heart Fail.
Volume:	20
Number:	3
Page Range:	S. 536 - 545
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1879-0844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEYNE-STOKES RESPIRATION; LEFT-VENTRICULAR DYSFUNCTION; CARDIAC RESYNCHRONIZATION THERAPY; RANDOMIZED CONTROLLED-TRIAL; POSITIVE AIRWAY PRESSURE; CARDIOVERTER-DEFIBRILLATOR; AUTO-SERVOVENTILATION; EJECTION FRACTION; MORTALITY; PREVALENCE Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19333