Universität zu Köln

Pool, Eva-Maria ORCID: 0000-0001-8007-9588, Leimbach, Martha, Binder, Ellen, Nettekoven, Charlotte, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2018). Network dynamics engaged in the modulation of motor behavior in stroke patients. Hum. Brain Mapp., 39 (3). S. 1078 - 1093. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Stroke patients with motor deficits typically feature enhanced neural activity in several cortical areas when moving their affected hand. However, also healthy subjects may show higher levels of neural activity in tasks with higher motor demands. Therefore, the question arises to what extent stroke-related overactivity reflects performance-level-associated recruitment of neural resources rather than stroke-induced neural reorganization. We here investigated which areas in the lesioned brain enable the flexible adaption to varying motor demands compared to healthy subjects. Accordingly, eleven well-recovered left-hemispheric chronic stroke patients were scanned using functional magnetic resonance imaging. Motor system activity was assessed for fist closures at increasing movement frequencies performed with the affected/right or unaffected/left hand. In patients, an increasing movement rate of the affected hand was associated with stronger neural activity in ipsilesional/left primary motor cortex (M1) but unlike in healthy controls also in contralesional/right dorsolateral premotor cortex (PMd) and contralesional/right superior parietal lobule (SPL). Connectivity analyses using dynamic causal modeling revealed stronger coupling of right SPL onto affected/left M1 in patients but not in controls when moving the affected/right hand independent of the movement speed. Furthermore, coupling of right SPL was positively coupled with the active ipsilesional/left M1 when stroke patients moved their affected/right hand with increasing movement frequency. In summary, these findings are compatible with a supportive role of right SPL with respect to motor function of the paretic hand in the reorganized brain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pool, Eva-Maria UNSPECIFIED orcid.org/0000-0001-8007-9588 UNSPECIFIED Leimbach, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettekoven, Charlotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-193407
DOI:	10.1002/hbm.23872
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	39
Number:	3
Page Range:	S. 1078 - 1093
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR PARIETAL CORTEX; POSITRON-EMISSION-TOMOGRAPHY; PREMOTOR CORTEX; EFFECTIVE CONNECTIVITY; CORTICAL CONNECTIVITY; MACAQUE MONKEY; HAND MOVEMENTS; INTRAPARIETAL SULCUS; FUNCTIONAL-ANATOMY; LONGITUDINAL FMRI Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19340