Universität zu Köln

Basner, Mathias, Nasrini, Jad ORCID: 0000-0003-3769-1186, Hermosillo, Emanuel, McGuire, Sarah, Dinges, David F., Moore, Tyler M., Gur, Ruben C., Rittweger, Joern, Mulder, Edwin, Wittkowski, Martin, Donoviel, Dorit, Stevens, Brian and Bershad, Eric M. (2018). Effects of-12 degrees head-down tilt with and without elevated levels of CO2 on cognitive performance: the SPACECOT study. J. Appl. Physiol., 124 (3). S. 750 - 761. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1601

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Abstract

Microgravity and elevated levels of CO2 are two common environmental stressors in spaceflight that may affect cognitive performance of astronauts. In this randomized, double-blind, crossover trial (SPACECOT), 6 healthy males (mean +/- SD age: 41 +/- 5 yr) were exposed to 0.04% (ambient air) and 0.5% CO2 concentrations during 26.5-h periods of -12 degrees head-down tilt (HDT) bed rest with a 1-wk washout period between exposures. Subjects performed the 10 tests of the Cognition Test Battery before and on average 0.1, 5.2, and 21.0 h after the initiation of HDT bed rest. HDT in ambient air induced a change in response strategy, with increased response speed (+0.19 SD; P = 0.0254) at the expense of accuracy (-0.19 SD; P = 0.2867), resulting in comparable cognitive efficiency. The observed effects were small and statistically significant for cognitive speed only. However, even small declines in accuracy can potentially cause errors during missioncritical tasks in spaceflight. Unexpectedly, exposure to 0.5% CO2 reversed the response strategy changes observed under HDT in ambient air. This was possibly related to hypercapnia-induced cerebrovascular reactivity that favors cortical regions in general and the frontal cortex in particular, or to the CNS arousing properties of mildly to moderately increased CO2 levels. There were no statistically significant time-in-CO2 effects for any cognitive outcome. The small sample size and the small effect sizes are major limitations of this study and its findings. The results should not be generalized beyond the group of investigated subjects until they are confirmed by adequately powered follow-up studies. NEW & NOTEWORTHY Simulating microgravity with exposure to 21 h of -12 degrees head-down tilt bed rest caused a change in response strategy on a range of cognitive tests, with a statistically significant increase in response speed at the expense of accuracy. Cognitive efficiency was not affected. The observed speed-accuracy tradeoff was small but may nevertheless be important for mission-critical tasks

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Basner, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Nasrini, Jad UNSPECIFIED orcid.org/0000-0003-3769-1186 UNSPECIFIED Hermosillo, Emanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED McGuire, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinges, David F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moore, Tyler M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gur, Ruben C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulder, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittkowski, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Donoviel, Dorit UNSPECIFIED UNSPECIFIED UNSPECIFIED Stevens, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bershad, Eric M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194176
DOI:	10.1152/japplphysiol.00855.2017
Journal or Publication Title:	J. Appl. Physiol.
Volume:	124
Number:	3
Page Range:	S. 750 - 761
Date:	2018
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPUTERIZED NEUROCOGNITIVE BATTERY; VIGILANCE TEST PVT; BED REST; WORKING-MEMORY; SLEEP-DEPRIVATION; CARBON-DIOXIDE; PSYCHOMOTOR PERFORMANCE; DECISION-MAKING; SPACEFLIGHT; VALIDATION Multiple languages Physiology; Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19417