Universität zu Köln

Empana, Jean-Philippe, Blom, Marieke T., Boettiger, Bernd W., Dagres, Nikolaos, Dekker, Jacqueline M., Gislason, Gunnar, Jouven, Xavier, Meitinger, Thomas, Ristagno, Giuseppe ORCID: 0000-0002-9235-4820, Schwartz, Peter J., Jonsson, Martin ORCID: 0000-0002-3539-8317, Tfelt-Hansen, Jacob ORCID: 0000-0003-3895-9316, Truhlar, Anatolij and Tan, Hanno L. (2018). Determinants of occurrence and survival after sudden cardiac arrest-A European perspective: The ESCAPE-NET project. Resuscitation, 124. S. 7 - 14. CLARE: ELSEVIER IRELAND LTD. ISSN 1873-1570

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Abstract

Aims: The ESCAPE-NET project (European Sudden Cardiac Arrest network-towards Prevention, Education and New Effective Treatments) aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. Methods: This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. Results: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum Munchen (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. Conclusion: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project. (c) 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Empana, Jean-Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Blom, Marieke T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boettiger, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dagres, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Dekker, Jacqueline M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gislason, Gunnar UNSPECIFIED UNSPECIFIED UNSPECIFIED Jouven, Xavier UNSPECIFIED UNSPECIFIED UNSPECIFIED Meitinger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ristagno, Giuseppe UNSPECIFIED orcid.org/0000-0002-9235-4820 UNSPECIFIED Schwartz, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonsson, Martin UNSPECIFIED orcid.org/0000-0002-3539-8317 UNSPECIFIED Tfelt-Hansen, Jacob UNSPECIFIED orcid.org/0000-0003-3895-9316 UNSPECIFIED Truhlar, Anatolij UNSPECIFIED UNSPECIFIED UNSPECIFIED Tan, Hanno L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194582
DOI:	10.1016/j.resuscitation.2017.12.011
Journal or Publication Title:	Resuscitation
Volume:	124
Page Range:	S. 7 - 14
Date:	2018
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1873-1570
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEATH; RISK; OUTCOMES; RATES; IMPLEMENTATION; EPIDEMIOLOGY; ASSOCIATION; GENETICS; SPECTRUM; DISPATCH Multiple languages Critical Care Medicine; Emergency Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19458