Universität zu Köln

Jessen, Frank, Spottke, Annika, Boecker, Henning, Brosseron, Frederic, Buerger, Katharina, Catak, Cihan, Fliessbach, Klaus, Franke, Christiana, Fuentes, Manuel, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Menne, Felix, Nestor, Peter ORCID: 0000-0002-5860-5921, Peters, Oliver, Priller, Josef ORCID: 0000-0001-7596-0979, Pross, Verena, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Schneider, Anja ORCID: 0000-0001-9540-8700, Speck, Oliver ORCID: 0000-0002-6019-5597, Spruth, Eike Jakob, Teipel, Stefan, Vukovich, Ruth, Westerteicher, Christine, Wiltfang, Jens ORCID: 0000-0003-1492-5330, Wolfsgruber, Steffen, Wagner, Michael ORCID: 0000-0003-2589-6440 and Duezel, Emrah (2018). Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE). Alzheimers Res. Ther., 10. LONDON: BMC. ISSN 1758-9193

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Abstract

Background: Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer's disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-mild cognitive impairment (pre-MCI) at-risk state of dementia, which emerges as a highly promising target for AD prevention. Methods: The German Center for Neurodegenerative Diseases (DZNE) is conducting the multicenter DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE), which focuses on the characterization of SCD in patients recruited from memory clinics. In addition, individuals with amnestic MCI, mild Alzheimer's dementia patients, first-degree relatives of patients with Alzheimer's dementia, and cognitively unimpaired control subjects are studied. The total number of subjects to be enrolled is 1000. Participants receive extensive clinical and neuropsychological assessments, magnetic resonance imaging, positron emission tomography, and biomaterial collection is perfomed. In this publication, we report cognitive and clinical data as well as apolipoprotein E (APOE) genotype and cerebrospinal fluid (CSF) biomarker results of the first 394 baseline data sets. Results: In comparison with the control group, patients with SCD showed slightly poorer performance on cognitive and functional measures (Alzheimer's Disease Assessment Scale-cognitive part, Clinical Dementia Rating, Functional Activities Questionnaire), with all mean scores in a range which would be considered unimpaired. APOE4 genotype was enriched in the SCD group in comparison to what would be expected in the population and the frequency was significantly higher in comparison to the control group. CSF A beta 42 was lower in the SCD group in comparison to the control group at a statistical trend with age as a covariate. There were no group differences in Tau or pTau concentrations between the SCD and the control groups. The differences in all measures between the MCI group and the AD group were as expected. Conclusions: The initial baseline data for DELCODE support the approach of using SCD in patients recruited through memory clinics as an enrichment strategy for late-stage preclinical AD. This is indicated by slightly lower performance in a range of measures in SCD in comparison to the control subjects as well as by enriched APOE4 frequency and lower CSF A beta 42 concentration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecker, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Brosseron, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Catak, Cihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Christiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuentes, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Janowitz, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilimann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Laske, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Menne, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestor, Peter UNSPECIFIED orcid.org/0000-0002-5860-5921 UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED orcid.org/0000-0001-7596-0979 UNSPECIFIED Pross, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Speck, Oliver UNSPECIFIED orcid.org/0000-0002-6019-5597 UNSPECIFIED Spruth, Eike Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Vukovich, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Westerteicher, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, Jens UNSPECIFIED orcid.org/0000-0003-1492-5330 UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-196112
DOI:	10.1186/s13195-017-0314-2
Journal or Publication Title:	Alzheimers Res. Ther.
Volume:	10
Date:	2018
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1758-9193
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBJECTIVE COGNITIVE DECLINE; CEREBROSPINAL-FLUID BIOMARKERS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; MEMORY IMPAIRMENT; CLINICAL PROGRESSION; RECOMMENDATIONS; COMPLAINTS; DEMENTIA Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19611