Universität zu Köln

Siegel, Corey A., Whitman, Cynthia B., Spiegel, Brennan M. R., Feagan, Brian, Sands, Bruce ORCID: 0000-0001-5762-5042, Loftus, Edward V., Jr., Panaccione, Remo, D'Haens, Geert, Bernstein, Charles N., Gearry, Richard, Ng, Siew C., Mantzaris, Gerassimos J., Sartor, Balfour, Silverberg, Mark S., Riddell, Robert, Koutroubakis, Ioannis E., O'Morain, Colm, Lakatos, Peter L., McGovern, Dermot P. B., Halfvarson, Jonas, Reinisch, Walter, Rogler, Gerhard, Kruis, Wolfgang, Tysk, Curt, Schreiber, Stefan, Danese, Silvio, Sandborn, William, Griffiths, Anne, Moum, Bjorn, Gasche, Christoph ORCID: 0000-0002-3752-6685, Pallone, Francesco, Travis, Simon, Panes, Julian, Colombel, Jean-Frederic, Hanauer, Stephen and Peyrin-Biroulet, Laurent (2018). Development of an index to define overall disease severity in IBD. Gut, 67 (2). S. 244 - 255. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3288

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Abstract

Background and aim Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC. Methods Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute. Results For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities. Conclusions Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siegel, Corey A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Whitman, Cynthia B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spiegel, Brennan M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feagan, Brian UNSPECIFIED UNSPECIFIED UNSPECIFIED Sands, Bruce UNSPECIFIED orcid.org/0000-0001-5762-5042 UNSPECIFIED Loftus, Edward V., Jr. UNSPECIFIED UNSPECIFIED UNSPECIFIED Panaccione, Remo UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Haens, Geert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernstein, Charles N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gearry, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Ng, Siew C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mantzaris, Gerassimos J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sartor, Balfour UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverberg, Mark S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riddell, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutroubakis, Ioannis E. UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Morain, Colm UNSPECIFIED UNSPECIFIED UNSPECIFIED Lakatos, Peter L. UNSPECIFIED UNSPECIFIED UNSPECIFIED McGovern, Dermot P. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Halfvarson, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinisch, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Rogler, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruis, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Tysk, Curt UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiber, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Danese, Silvio UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandborn, William UNSPECIFIED UNSPECIFIED UNSPECIFIED Griffiths, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Moum, Bjorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Gasche, Christoph UNSPECIFIED orcid.org/0000-0002-3752-6685 UNSPECIFIED Pallone, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Travis, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Panes, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Colombel, Jean-Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanauer, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Peyrin-Biroulet, Laurent UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-196465
DOI:	10.1136/gutjnl-2016-312648
Journal or Publication Title:	Gut
Volume:	67
Number:	2
Page Range:	S. 244 - 255
Date:	2018
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-3288
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CROHNS-DISEASE; ULCERATIVE-COLITIS; CONJOINT-ANALYSIS; TREATMENT RISKS; PREFERENCES; MANAGEMENT; PREDICTORS; TOLERANT; THERAPY; DAMAGE Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19646