Roedel, Franz, Steinhaeuser, Kerstin, Kreis, Nina-Naomi ORCID: 0000-0003-4304-0160, Friemel, Alexandra, Martin, Daniel ORCID: 0000-0002-8674-2683, Wieland, Ulrike, Rave-Fraenk, Margret, Balermpas, Panagiotis ORCID: 0000-0001-5261-6446, Fokas, Emmanouil, Louwen, Frank, Roedel, Claus and Yuan, Juping ORCID: 0000-0003-0694-0565 (2018). Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy. Radiother. Oncol., 126 (2). S. 214 - 222. CLARE: ELSEVIER IRELAND LTD. ISSN 0167-8140

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Abstract

Background: RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. Materials and methods: In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS). Results: We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p < 0.0001), whereas in multivariate analyses RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012). Conclusion: These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy. (C) 2017 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 126 (2018) 214-221

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roedel, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinhaeuser, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreis, Nina-NaomiUNSPECIFIEDorcid.org/0000-0003-4304-0160UNSPECIFIED
Friemel, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, DanielUNSPECIFIEDorcid.org/0000-0002-8674-2683UNSPECIFIED
Wieland, UlrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rave-Fraenk, MargretUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balermpas, PanagiotisUNSPECIFIEDorcid.org/0000-0001-5261-6446UNSPECIFIED
Fokas, EmmanouilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Louwen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roedel, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yuan, JupingUNSPECIFIEDorcid.org/0000-0003-0694-0565UNSPECIFIED
URN: urn:nbn:de:hbz:38-197003
DOI: 10.1016/j.radonc.2017.10.028
Journal or Publication Title: Radiother. Oncol.
Volume: 126
Number: 2
Page Range: S. 214 - 222
Date: 2018
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 0167-8140
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HUMAN HEPATOCELLULAR-CARCINOMA; HUMAN-PAPILLOMAVIRUS; FOLLOW-UP; CANCER; CHEMORADIATION; SURVIVAL; PATHWAY; HEAD; NECK; HPVMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19700

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