Universität zu Köln

Annecke, Thorsten ORCID: 0000-0002-2496-4432, Hohn, Andreas, Boell, B. and Kochanek, Matthias ORCID: 0000-0002-4766-4651 (2018). Krebspatienten in der operativen Intensivmedizin. Anaesthesist, 67 (2). S. 83 - 93. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-055X

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Abstract

Cancer is one of the leading causes of death worldwide. New targeted and individualized therapies and drugs provide a survival benefit for an increasing number of patients, but can also cause severe side effects. An increasing number of oncology patients are admitted to intensive care units (ICU) because of cancer-related complications or treatment-associated side effects. Postoperative care, respiratory distress and sepsis are the leading causes for admission. Tumor mass syndromes and tumor lysis may require urgent treatment. Traditional anticancer chemotherapy is associated with infections and immunosuppression. Newer agents are generally well-tolerated and side effects are mild or moderate, but overwhelming inflammation and autoimmunity can also occur. Cellular treatment, such as with chimeric antigen receptor modified TaEurocells, monoclonal and bispecific antibodies targeting immune effectors and tumor cells are associated with cytokine release syndrome (CRS) with hypotension, skin reactions and fever. It is related to excessively high levels of inflammatory cytokines. Immune checkpoint inhibitors can lead to immune-related adverse events (IRAEs), such as colitis and endocrine disorders. Noninfectious respiratory complications, such as pneumonitis can also occur. Recent studies revealed that short-term and medium-term survival of cancer patients is better than previously expected. In this review article we summarize diagnostic and treatment strategies for common life-threatening complications and emergencies requiring ICU admission. Furthermore, strategies for rational admission policies are presented.

Item Type:	Journal Article
Translated title:	Title Language Cancer patients in operative intensive care medicine English
Creators:	Creators Email ORCID ORCID Put Code Annecke, Thorsten UNSPECIFIED orcid.org/0000-0002-2496-4432 UNSPECIFIED Hohn, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Matthias UNSPECIFIED orcid.org/0000-0002-4766-4651 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197962
DOI:	10.1007/s00101-018-0406-9
Journal or Publication Title:	Anaesthesist
Volume:	67
Number:	2
Page Range:	S. 83 - 93
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-055X
Language:	German
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language FEBRILE NEUTROPENIC PATIENTS; CRITICALLY-ILL PATIENTS; INTERNATIONAL GUIDELINES; RESPIRATORY-FAILURE; MANAGEMENT; IMMUNOTHERAPY; BEVACIZUMAB; TOXICITIES; SEPSIS; UNIT Multiple languages Anesthesiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19796