Kasmann, Lukas, Niyazi, Maximilian, Blanck, Oliver ORCID: 0000-0003-1391-1308, Baues, Christian, Baumann, Rene, Dobiasch, Sophie, Eze, Chukwuka, Fleischmann, Daniel, Gauer, Tobias, Giordano, Frank A., Goy, Yvonne, Hausmann, Jan, Henkenberens, Christoph, Kaul, David, Klook, Lisa, Krug, David ORCID: 0000-0001-8811-5416, Maeurer, Matthias, Panje, Cedric M., Rosenbrock, Johannes, Sautter, Lisa, Schmitt, Daniela ORCID: 0000-0002-9657-0715, Suess, Christoph, Thieme, Alexander H., Trommer-Nestler, Maike, Ziegler, Sonia ORCID: 0000-0001-8655-3172, Ebert, Nadja, Medenwald, Daniel and Ostheimer, Christian (2018). Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of stage III non-small cell lung cancer A systematic review. Strahlenther. Onkol., 194 (2). S. 79 - 91. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Lung cancer remains the leading cause of cancer-related mortality worldwide. Stage III non-small cell lung cancer (NSCLC) includes heterogeneous presentation of the disease including lymph node involvement and large tumour volumes with infiltration of the mediastinum, heart or spine. In the treatment of stage III NSCLC an interdisciplinary approach including radiotherapy is considered standard of care with acceptable toxicity and improved clinical outcome concerning local control. Furthermore, gross tumour volume (GTV) changes during definitive radiotherapy would allow for adaptive replanning which offers normal tissue sparing and dose escalation. A literature review was conducted to describe the predictive value of GTV changes during definitive radiotherapy especially focussing on overall survival. The literature search was conducted in a two-step review process using PubMedA (R)/MedlineA (R) with the key words stage III non-small cell lung cancer and radiotherapy and tumour volume and prognostic factors. After final consideration 17, 14 and 9 studies with a total of 2516, 784 and 639 patients on predictive impact of GTV, GTV changes and its impact on overall survival, respectively, for definitive radiotherapy for stage III NSCLC were included in this review. Initial GTV is an important prognostic factor for overall survival in several studies, but the time of evaluation and the value of histology need to be further investigated. GTV changes during RT differ widely, optimal timing for re-evaluation of GTV and their predictive value for prognosis needs to be clarified. The prognostic value of GTV changes is unclear due to varying study qualities, re-evaluation time and conflicting results. The main findings were that the clinical impact of GTV changes during definitive radiotherapy is still unclear due to heterogeneous study designs with varying quality. Several potential confounding variables were found and need to be considered for future studies to evaluate GTV changes during definitive radiotherapy with respect to treatment outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kasmann, LukasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niyazi, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blanck, OliverUNSPECIFIEDorcid.org/0000-0003-1391-1308UNSPECIFIED
Baues, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumann, ReneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobiasch, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eze, ChukwukaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleischmann, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gauer, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giordano, Frank A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goy, YvonneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hausmann, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkenberens, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaul, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klook, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krug, DavidUNSPECIFIEDorcid.org/0000-0001-8811-5416UNSPECIFIED
Maeurer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panje, Cedric M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenbrock, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sautter, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, DanielaUNSPECIFIEDorcid.org/0000-0002-9657-0715UNSPECIFIED
Suess, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thieme, Alexander H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trommer-Nestler, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, SoniaUNSPECIFIEDorcid.org/0000-0001-8655-3172UNSPECIFIED
Ebert, NadjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medenwald, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostheimer, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-198048
DOI: 10.1007/s00066-017-1221-y
Journal or Publication Title: Strahlenther. Onkol.
Volume: 194
Number: 2
Page Range: S. 79 - 91
Date: 2018
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-099X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTENSITY-MODULATED RADIOTHERAPY; 3D CONFORMAL RADIOTHERAPY; RADIATION-THERAPY; CONCURRENT CHEMORADIOTHERAPY; F-18-FDG PET/CT; DOSE-ESCALATION; PHASE-III; TNM STAGE; SURVIVAL; CTMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19804

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