Universität zu Köln

Kirmse, Knut ORCID: 0000-0002-9206-214X, Huebner, Christian A., Isbrandt, Dirk, Witte, Otto W. and Holthoff, Knut (2018). GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages. Neuroscientist, 24 (1). S. 36 - 54. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1089-4098

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Abstract

In recent years, considerable progress has been achieved in deciphering the cellular and network functions of GABAergic transmission in the intact developing brain. First, in vivo studies in non-mammalian and mammalian species confirmed the long-held assumption that GABA acts as a mainly depolarizing neurotransmitter at early developmental stages. At the same time, GABAergic transmission was shown to spatiotemporally constrain spontaneous cortical activity, whereas firm evidence for GABAergic excitation in vivo is currently missing. Second, there is a growing body of evidence indicating that depolarizing GABA may contribute to the activity-dependent refinement of neural circuits. Third, alterations in GABA actions have been causally linked to developmental brain disorders and identified as potential targets of timed prophylactic interventions. In this article, we review these major recent findings and argue that both depolarizing and inhibitory GABA actions may be crucial for physiological brain maturation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kirmse, Knut UNSPECIFIED orcid.org/0000-0002-9206-214X UNSPECIFIED Huebner, Christian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Isbrandt, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Witte, Otto W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holthoff, Knut UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-198322
DOI:	10.1177/1073858417701382
Journal or Publication Title:	Neuroscientist
Volume:	24
Number:	1
Page Range:	S. 36 - 54
Date:	2018
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1089-4098
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CATION-CHLORIDE COTRANSPORTERS; HYPERPOLARIZING GLYCINE ACTION; SUPERIOR OLIVARY COMPLEX; GAMMA-AMINOBUTYRIC-ACID; INTRACELLULAR CHLORIDE; DEVELOPING NEOCORTEX; POSTSYNAPTIC INHIBITION; NEURONAL EXCITABILITY; GABA DEPOLARIZATION; PYRAMIDAL NEURONS Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19832