Mikropoulos, Christos, Selkirk, Christina G. Hutten, Saya, Sibel, Bancroft, Elizabeth ORCID: 0000-0002-5482-5660, Vertosick, Emily, Dadaev, Tokhir, Brendler, Charles, Page, Elizabeth, Dias, Alexander, Evans, D. Gareth, Rothwell, Jeanette, Maehle, Lovise, Axcrona, Karol, Richardson, Kate, Eccles, Diana ORCID: 0000-0002-9935-3169, Jensen, Thomas, Osther, Palle J., van Asperen, Christi J., Vasen, Hans ORCID: 0000-0003-2682-2603, Kiemeney, Lambertus A. ORCID: 0000-0002-2368-1326, Ringelberg, Janneke, Cybulski, Cezary, Wokolorczyk, Dominika, Hart, Rachel, Glover, Wayne, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadalo, Lidia ORCID: 0000-0002-1736-0112, Oldenburg, Rogier, Cremers, Ruben, Verhaegh, Gerald ORCID: 0000-0003-0227-2280, van Zelst-Stams, Wendy A., Oosterwijk, Jan C., Cook, Jackie, Rosario, Derek J., Buys, Saundra S., Conner, Tom, Domchek, Susan, Powers, Jacquelyn, Ausems, Margreet G. E. M., Teixeira, Manuel R., Maia, Sofia, Izatt, Louise, Schmutzler, Rita, Rhiem, Kerstin, Foulkes, William D., Boshari, Talia ORCID: 0000-0002-4838-9276, Davidson, Rosemarie, Ruijs, Marielle, Helderman-van den Enden, Apollonia T. J. M., Andrews, Lesley, Walker, Lisa, Snape, Katie, Henderson, Alex, Jobson, Irene, Lindeman, Geoffrey J., Liljegren, Annelie, Harris, Marion, Adank, Muriel A., Kirk, Judy, Taylor, Amy, Susman, Rachel, Chen-Shtoyerman, Rakefet, Pachter, Nicholas, Spigelman, Allan, Side, Lucy, Zgajnar, Janez, Mora, Josefina, Brewer, Carole, Gadea, Neus, Brady, Angela F., Gallagher, David, van Os, Theo, Donaldson, Alan, Stefansdottir, Vigdis ORCID: 0000-0003-4451-3126, Barwell, Julian, James, Paul A., Murphy, Declan, Friedman, Eitan, Nicolai, Nicola ORCID: 0000-0002-5718-2699, Greenhalgh, Lynn, Obeid, Elias, Murthy, Vedang, Copakova, Lucia, McGrath, John, Teo, Soo-Hwang, Strom, Sara, Kast, Karin, Leongamornlert, Daniel A., Chamberlain, Anthony, Pope, Jenny, Newlin, Anna C., Aaronson, Neil, Ardern-Jones, Audrey, Bangma, Chris, Castro, Elena ORCID: 0000-0002-3691-6454, Dearnaley, David, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher S., Gronberg, Henrik, Hamdy, Freddie C., Johannsson, Oskar, Khoo, Vincent, Lubinski, Jan ORCID: 0000-0003-2931-3003, Grindedal, Eli Marie, McKinley, Joanne, Shackleton, Kylie, Mitra, Anita V., Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Tricker, Karen, Moss, Sue, Kote-Jarai, Zsofia, Vickers, Andrew, Lilja, Hans, Helfand, Brian T. and Eeles, Rosalind A. (2018). Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. Br. J. Cancer, 118 (2). S. 266 - 277. LONDON: NATURE PUBLISHING GROUP. ISSN 1532-1827

Full text not available from this repository.

Abstract

Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. Methods: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. Results: 1634 participants had >= 3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml(-1), PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P = 0.031) and BRCA2 status and PSAV (P = 0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. Conclusions: PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mikropoulos, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Selkirk, Christina G. HuttenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saya, SibelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bancroft, ElizabethUNSPECIFIEDorcid.org/0000-0002-5482-5660UNSPECIFIED
Vertosick, EmilyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dadaev, TokhirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brendler, CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Page, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dias, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothwell, JeanetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maehle, LoviseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Axcrona, KarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richardson, KateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eccles, DianaUNSPECIFIEDorcid.org/0000-0002-9935-3169UNSPECIFIED
Jensen, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osther, Palle J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, Christi J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasen, HansUNSPECIFIEDorcid.org/0000-0003-2682-2603UNSPECIFIED
Kiemeney, Lambertus A.UNSPECIFIEDorcid.org/0000-0002-2368-1326UNSPECIFIED
Ringelberg, JannekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cybulski, CezaryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wokolorczyk, DominikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hart, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glover, WayneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lam, JimmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salinas, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feliubadalo, LidiaUNSPECIFIEDorcid.org/0000-0002-1736-0112UNSPECIFIED
Oldenburg, RogierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cremers, RubenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhaegh, GeraldUNSPECIFIEDorcid.org/0000-0003-0227-2280UNSPECIFIED
van Zelst-Stams, Wendy A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oosterwijk, Jan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cook, JackieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosario, Derek J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conner, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domchek, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Powers, JacquelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ausems, Margreet G. E. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teixeira, Manuel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maia, SofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foulkes, William D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boshari, TaliaUNSPECIFIEDorcid.org/0000-0002-4838-9276UNSPECIFIED
Davidson, RosemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruijs, MarielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helderman-van den Enden, Apollonia T. J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrews, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snape, KatieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jobson, IreneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindeman, Geoffrey J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liljegren, AnnelieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harris, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adank, Muriel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirk, JudyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susman, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen-Shtoyerman, RakefetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pachter, NicholasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spigelman, AllanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Side, LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zgajnar, JanezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mora, JosefinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brewer, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gadea, NeusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brady, Angela F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallagher, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Os, TheoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Donaldson, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stefansdottir, VigdisUNSPECIFIEDorcid.org/0000-0003-4451-3126UNSPECIFIED
Barwell, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
James, Paul A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murphy, DeclanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedman, EitanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nicolai, NicolaUNSPECIFIEDorcid.org/0000-0002-5718-2699UNSPECIFIED
Greenhalgh, LynnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obeid, EliasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murthy, VedangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Copakova, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGrath, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teo, Soo-HwangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strom, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leongamornlert, Daniel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chamberlain, AnthonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pope, JennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newlin, Anna C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaronson, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ardern-Jones, AudreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bangma, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castro, ElenaUNSPECIFIEDorcid.org/0000-0002-3691-6454UNSPECIFIED
Dearnaley, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eyfjord, JorunnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falconer, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foster, Christopher S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gronberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamdy, Freddie C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannsson, OskarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khoo, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lubinski, JanUNSPECIFIEDorcid.org/0000-0003-2931-3003UNSPECIFIED
Grindedal, Eli MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKinley, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shackleton, KylieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitra, Anita V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moynihan, ClareUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rennert, GadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suri, MohnishUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tricker, KarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moss, SueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZsofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vickers, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lilja, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helfand, Brian T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, Rosalind A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-198547
DOI: 10.1038/bjc.2017.429
Journal or Publication Title: Br. J. Cancer
Volume: 118
Number: 2
Page Range: S. 266 - 277
Date: 2018
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1532-1827
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BRCA2 MUTATION CARRIERS; PSA VELOCITY; RISK; CURABILITY; INCREASE; WINDOW; IMPACT; DEATHMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19854

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item