Universität zu Köln

Dolscheid-Pommerich, Ramona C., Dolscheid, Sarah ORCID: 0000-0001-9104-6386, Eichhorn, Lars ORCID: 0000-0002-9769-0639, Stoffel-Wagner, Birgit and Graeff, Ingo (2018). Thrombolysis in stroke patients: Comparability of point-of-care versus central laboratory international normalized ratio. PLoS One, 13 (1). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background In acute stroke patients, thrombolysis is one gold standard therapy option within the first four hours after the ischemic event. A contraindication for thrombolysis is an International Normalized Ratio (INR) value > 1.7. Since time is brain, rapid and reliable INR results are fundamental. Aim was to compare INR values determined by central laboratory (CL) analyzer and Point-of-Care Testing(POCT)-device and to evaluate the quality of POCT performance in cases of potential therapeutic thrombolysis at a certified stroke unit. Methods In 153 patients INR measurements using POCT-devices (HEMOCHRON Signature Elite (R)) were compared to INR measurements (BCS (R) XP) performed at the central laboratory. Outlier evaluation was performed regarding the critical thrombolysis cut-off. Results Overall, we demonstrated a significant correlation (r = 0.809, p<0.0001) between both measurement methods. Mean value of the absolute difference between CL-INR and POCT-INR measurements was 0.23. In 95.4% of these cases, no differences regarding the critical cutoff (INR 1.7) were observed. POCT-INR values tended to be higher than the CL-INR values (p = 0.01). In 4.6% cases, a different value regarding thrombolysis cut-off was found. All patients were >75 years. Conclusions POCT-INR measurements based on our POCT concept are suitable to determine INR values in critical stroke patients. Nevertheless, outlier evaluation is mandatory.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dolscheid-Pommerich, Ramona C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolscheid, Sarah UNSPECIFIED orcid.org/0000-0001-9104-6386 UNSPECIFIED Eichhorn, Lars UNSPECIFIED orcid.org/0000-0002-9769-0639 UNSPECIFIED Stoffel-Wagner, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeff, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-198954
DOI:	10.1371/journal.pone.0190867
Journal or Publication Title:	PLoS One
Volume:	13
Number:	1
Date:	2018
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE ISCHEMIC-STROKE; INR; COAGULATION; HEMORRHAGE; AGREEMENT; POCT; UNIT Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19895