Universität zu Köln

Michieletto, Davide, Chiang, Michael, Coli, Davide, Papantonis, Argyris ORCID: 0000-0001-7551-1073, Orlandini, Enzo, Cook, Peter R. and Marenduzzo, Davide ORCID: 0000-0003-3974-4915 (2018). Shaping epigenetic memory via genomic bookmarking. Nucleic Acids Res., 46 (1). S. 83 - 94. OXFORD: OXFORD UNIV PRESS. ISSN 1362-4962

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Abstract

Reconciling the stability of epigenetic patterns with the rapid turnover of histone modifications and their adaptability to external stimuli is an outstanding challenge. Here, we propose a new biophysical mechanism that can establish and maintain robust yet plastic epigenetic domains via genomic bookmarking (GBM). We model chromatin as a recolourable polymer whose segments bear non-permanent histone marks (or colours) which can be modified by 'writer' proteins. The three-dimensional chromatin organisation is mediated by protein bridges, or 'readers', such as Polycomb Repressive Complexes and Transcription Factors. The coupling between readers and writers drives spreading of biochemical marks and sustains the memory of local chromatin states across replication and mitosis. In contrast, GBM-targeted perturbations destabilise the epigenetic patterns. Strikingly, we demonstrate that GBM alone can explain the full distribution of Polycomb marks in a whole Drosophila chromosome. We finally suggest that our model provides a starting point for an understanding of the biophysics of cellular differentiation and reprogramming.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Michieletto, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Chiang, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Coli, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Papantonis, Argyris UNSPECIFIED orcid.org/0000-0001-7551-1073 UNSPECIFIED Orlandini, Enzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Cook, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marenduzzo, Davide UNSPECIFIED orcid.org/0000-0003-3974-4915 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-199016
DOI:	10.1093/nar/gkx1200
Journal or Publication Title:	Nucleic Acids Res.
Volume:	46
Number:	1
Page Range:	S. 83 - 94
Date:	2018
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1362-4962
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HISTONE MODIFICATIONS; MITOTIC BOOKMARKING; TOPOLOGICAL DOMAINS; RESPONSE ELEMENTS; HUMAN-CHROMOSOMES; CHROMATIN; INHERITANCE; DYNAMICS; BINDING; PLURIPOTENCY Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19901