Universität zu Köln

Schenck, Sandra, Rosenbauer, Joachim ORCID: 0000-0002-6086-2230, Niewerth, Martina, Klotsche, Jens, Minden, Kirsten, Schwarz, Tobias, Foeldvari, Ivan, Horneff, Gerd, Weller-Heinemann, Frank, Holl, Reinhard W. and Thon, Angelika (2018). Comorbidity of Type 1 Diabetes Mellitus in Patients with Juvenile Idiopathic Arthritis. J. Pediatr., 192. S. 196 - 204. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6833

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Abstract

Objectives To determine the prevalence of type 1 diabetes mellitus (T1D) in patients with juvenile idiopathic arthritis (JIA) and to characterize patients having both. Study design Diabetes comorbidity was recorded in the National Pediatric Rheumatologic Database since 2012. Data from the North Rhine-Westphalian diabetes registry served as the reference population for the prevalence of diabetes in the general population. The National Pediatric Rheumatologic Database data were indirectly standardized for age and sex for comparison with the general population. The diabetes prevalence ratio was calculated using the Poisson regression model. Results The analysis included 12 269 patients with JIA. A total of 58 patients had comorbid T1D, and the diabetes prevalence was 0.5%. The mean age was 11.6 years at the time of documentation, and the mean disease duration was 4.2 years. Compared with the general population, the prevalence of diabetes in patients with JIA was significantly increased (prevalence ratio 1.76 [95% CI 1.34; 2.28], P < .001). The onset of diabetes in patients with JIA was earlier than that reported in the reference data. Sixty-three percent of patients developed T1D before JIA. On average, diabetes onset was 56 months before the onset of JIA. Patients who first developed JIA developed T1D on average 40 months later. The majority of patients had not received disease-modifying antirheumatic drugs before diabetes onset. Conclusions T1D occurs more frequently in patients with JIA than in the general population. The likelihood of T1D occurrence appears to be slightly higher before JIA manifestation and without disease-modifying antirheumatic drug therapy after JIA onset.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schenck, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenbauer, Joachim UNSPECIFIED orcid.org/0000-0002-6086-2230 UNSPECIFIED Niewerth, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Klotsche, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Minden, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Foeldvari, Ivan UNSPECIFIED UNSPECIFIED UNSPECIFIED Horneff, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Weller-Heinemann, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Holl, Reinhard W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thon, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200675
DOI:	10.1016/j.jpeds.2017.07.050
Journal or Publication Title:	J. Pediatr.
Volume:	192
Page Range:	S. 196 - 204
Date:	2018
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-6833
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RHEUMATOID-ARTHRITIS; HASHIMOTOS-THYROIDITIS; AUTOIMMUNE-DISEASE; CHILDREN; RISK; ASSOCIATION; ADOLESCENTS; CHILDHOOD; CLASSIFICATION; SUSCEPTIBILITY Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20067