Universität zu Köln

Predel, Reinhard, Neupert, Susanne, Derst, Christian, Reinhardt, Klaus and Wegener, Christian ORCID: 0000-0003-4481-3567 (2018). Neuropeptidomics of the Bed Bug Cimex lectularius. J. Proteome Res., 17 (1). S. 440 - 455. WASHINGTON: AMER CHEMICAL SOC. ISSN 1535-3907

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Abstract

The bed bug Cimex lectularius is a globally distributed human ectoparasite with fascinating biology. It has recently acquired resistance against a broad range of insecticides, causing a worldwide increase in bed bug infestations. The recent annotation of the bed bug genome revealed a full complement of neuropeptide and neuropeptide receptor genes in this species. With regard to the biology of C. lectularius, neuropeptide signaling is especially interesting because it regulates feeding, diuresis, digestion, as well as reproduction and also provides potential new targets for chemical control. To identify which neuropeptides are translated from the genome-predicted genes, we performed a comprehensive peptidomic analysis of the central nervous system of the bed bug. We identified in total 144 different peptides from 29 precursors, of which at least 67 likely present bioactive mature neuropeptides. C. lectularius corazonin and myosuppressin are unique and deviate considerably from the canonical insect consensus sequences. Several identified neuropeptides likely act as hormones, as evidenced by the occurrence of respective mass signals and immunoreactivity in neurohemal structures. Our data provide the most comprehensive peptidome of a Heteropteran species so far and in comparison suggest that a hematophageous life style does not require qualitative adaptations of the insect peptidome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Predel, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Neupert, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Derst, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wegener, Christian UNSPECIFIED orcid.org/0000-0003-4481-3567 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200686
DOI:	10.1021/acs.jproteome.7b00630
Journal or Publication Title:	J. Proteome Res.
Volume:	17
Number:	1
Page Range:	S. 440 - 455
Date:	2018
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1535-3907
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN COUPLED RECEPTORS; CENTRAL-NERVOUS-SYSTEM; CHAGAS-DISEASE VECTOR; BLOOD-FEEDING BUG; RHODNIUS-PROLIXUS; DROSOPHILA-MELANOGASTER; NEUROHEMAL SYSTEM; PEST-CONTROL; PEPTIDES; INSECT Multiple languages Biochemical Research Methods Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20068